Lipoprotein(a) levels and apolipoprotein(a) polymorphism in type 1 diabetes mellitus: relationships to microvascular and neurological complications |
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Authors: | C Gazzaruso A Garzaniti P Buscaglia G D'Annunzio A Porta G Vandelli R Lorini G Finardi P Fratino D Geroldi |
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Institution: | (1) Department of Internal Medicine and Medical Therapeutics, Section of Internal Medicine, Vascular and Metabolic Diseases, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy, IT;(2) Department of Pediatrics, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy, IT;(3) Institute of Ophthalmology, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy, IT;(4) Department of Internal Medicine and Medical Therapeutics, Polo Universitario Convenzionato Città di Pavia, University of Pavia, Pavia, Italy, IT;(5) Policlinico San Matteo – Clinica Medica I, Piazzale Golgi 2, I-27100 Pavia, Italy, IT |
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Abstract: | To investigate plasma concentrations of lipoprotein(a) Lp(a)] and apolipoprotein(a) apo(a)] polymorphism in relation to
the presence of microvascular and neurological complications in type 1 diabetes mellitus, 118 young diabetic patients and
127 age-matched controls were recruited. Lp(a) levels were higher in patients than in controls, but the apo(a) isoforms distribution
did not differ between the two groups higher prevalence of isoforms of high relative molecular mass (RMM) in both groups].
Microalbuminuric patients had Lp(a) levels significantly greater than normoalbuminuric patients, and normoalbuminuric patients
showed higher Lp(a) levels than controls. Patients with retinopathy or neuropathy showed similar Lp(a) levels to those without
retinopathy or neuropathy. No differences in apo(a) isoforms frequencies were observed between subgroups with and without
complications (higher prevalence of isoforms of high RMM in every subgroup). However, among patients with retinopathy, those
with proliferative retinopathy had higher Lp(a) levels and a different apo(a) isoforms distribution (higher prevalence of
isoforms of low RMM) than those with non-proliferative and background retinopathy (higher prevalence of isoforms of high RMM).
Our data suggest that young type 1 diabetic patients without microalbuminuria have Lp(a) levels higher than healthy subjects
of the same age. Lp(a) levels are further increased in microalbuminuric patients. High Lp(a) levels and apo(a) isoforms of
low RMM seem to be associated with the presence of proliferative retinopathy, but have no relation to neuropathy.
Received: 23 June 1997 / Accepted in revised form: 27 November 1997 |
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Keywords: | Lipoprotein(a) Apolipoprotein(a) polymorphism Insulin-dependent diabetes mellitus Microangiopathy Neuropathy |
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