二甲基甘氨酸对脊髓神经元的作用

IntroductionN,N- dimethyl glycine,a nutrient[1] ,a methy-lated glycine,also known as pangamic acid and cal-cium pangamate,was once considered to be Vita-min B- 1 5. However dietary deficiency of DMGdoes not cause any known disease[2 ] .DMG is pre-sent in low levels in meat,seeds and grains[3 ] .Itisclaimed to improve speech and behavioral patternsin mentally retarded and autistic children.It isclaimed to be non- toxic and with no undesirableside effects[4 ] .It has been described as a new …

EFFECT OF DIMETHYL GLYCINE ON SPINAL NEURONS

N, N dimethyl glycine(DMG),a food supplement, is claimed to be non toxic and is known for its immunoprotective and stamina building property. It improves CNS functions,mainly speech in autistic children, causes behavioral improvement and decreases seizures. To study its effect on the neurons on the ventral half of the cervical enlargement of the spinal cord, DMG dissolved in distilled water was given to 21 day old albino mice at a dose of 20mg/kg body weight per day for 30 days. The ventral half of the cervical enlargement of the spinal cord was studied morphologically. The results showed a significant decrease in the neuron count in the 15 25 micron range in the DMG treated mice. No significant change was observed in the area of gray matter or white matter or total area. Neurons having a diameter of more than 25 microns showed no change in the cell count.These results suggest a cytotoxic damage caused by DMG.