Delayed-Type Hypersensitivity Response in Mice to Treponema Pallidum |
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| Authors: | John R. Klein Andrew A. Monjan |
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| Affiliation: | a Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD |
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| Abstract: | C3H/HeJ mice which had been primed with either virulent or killed T. pailidum were studied for in vivo delayed-type hypersensitivity (DTH) responses to T. pallidum following local footpad challenge. Mice sustaining a chronic infection of 5 months duration failed to develop a DTH to treponemal antigens, whereas priming by a single intravenous injection with killed organisms resulted in a significant DTH response in mice when challenged 5 days later. Treatment of mice prior to priming with a single sublethal dose of cyclophosphamide (100 mg/kg body weight) not only failed to potentiate T. pallidum-DTH, but abrogated the response observed in untreated primed animals. |
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