-765G>C COX-2基因多态性与胃癌易感性的Meta分析

 目的探讨-765G>C COX-2基因多态性与胃癌易感性的关系。方法计算机检索MEDLINE、EMBASE、CBMDisc 数据
库，手工检索相关杂志。由两名评价员独立检索和提取资料并交叉核对，纳入相关病例对照试验。Meta 分析软件是Cochrane 协
作网提供的RevMan5.0.23。结果共纳入病例对照试验8 个，包括3 880 例病人，其中病例组1 617 例，对照组2 263例。Meta
分析结果显示： --765G等位基因与胃癌发生的易感性有一定的相关性（OR=1.71，95%CI：1.01-2.90，P=0.05）；亚组分析结果提示
在高加索人中--765G等位基因不是胃癌的易感性因素（OR=1.19，95%CI= 0.65-2.15，P=0.58），在亚洲人（OR=1.87，95%CI=1.19-
2.94，P=0.006）和印度人（OR=8.38，95%CI= 4.34-16.16， P< 0.00001）中是易感性因素，在荷兰人中-765C等位基因是胃癌的易
感性因素（OR=0.53，95%CI= 0.33-0.87， P< 0.00001）。结论--765G等位基因与胃癌的易感性有一定的相关性，且不同种族其
易感性有差异。

Genetic Polymorphism of-765G>C of Cyclooxygenase-2 and Susceptibility to Gastric Carcinoma:A Meta-analysis

Objective To investigate the association between the-765G>C of cyclooxygenase-2(COX-2)genetic polymorphism and susceptibility to gastric cancer(GC)by conducting a meta-analysis.Methods Publications addressing the relationship between the-765G>C of COX-2 genetic polymorphism and susceptibility to GC were selected from the MEDLINE,EMBASE,CBMdisc databases on computer and relevant journals were searched manually.Data were extracted and cross-checked from the case-control studies by 2 independent reviewers.The ...