|
|||||
|
|
No association between the FXYD6 gene and schizophrenia in the Chinese Han population |
|
| Authors: | Jing Zhang Ronglin Che Xingwang Li Wei Tang Qian Zhao Ruqi Tang Yang Wang Zhao Zhang Jue Ji Fengping Yang Yongyong Shi Weidong Ji Guoyin Feng Guang He |
| Affiliation: | a Bio-X Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China b Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China c Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, PR China d Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, PR China e Bio-X Life Science Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China f Institute of Neuropsychiatric Science and Systems Biological Medicine, Changning Institute of Mental Health, The Bio-X Center Hospital, Shanghai, China |
| Abstract: | Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia patients and 1514 healthy controls. We also compared the expression levels of FXYD6 in lymphocytes in 86 schizophrenia patients and 94 controls. No association was detected either in D11S1998 or the 8 SNPs. No difference was found in expression level between patients and controls. Our study suggests that FXYD6 does not play a role in schizophrenia in the Chinese Han population. |
| Keywords: | FXYD6 Association Chinese Han population |
| 本文献已被 ScienceDirect 等数据库收录！ | |