Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes |
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Authors: | Kati Koido,Triin Eller,Sulev Kõ ks,Tanel Traks,Jakov Shlik,Eero Vasar,Eduard Maron |
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Affiliation: | a Department of Physiology, University of Tartu, Tartu, Estonia b Centre of Excellence for Translational Medicine, University of Tartu, Tartu, Estonia c Department of Psychiatry, University of Tartu, Tartu, Estonia d Clinic of Dermatology, University of Tartu, Tartu, Estonia e Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada f Research Department of Mental Health, North Estonian Regional Hospital, Psychiatry Clinic, Tallinn, Estonia g Estonian Genome Foundation, University of Tartu, Tartu, Estonia |
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Abstract: | Genetic regulation of immune system and inflammatory response may be related to the pathogenesis and manifestations of mood and anxiety disorders. In the present study we examined a range of single-nucleotide polymorphisms (SNP) in chromosomal region 1q32, the locus of interleukin 10 (IL10) gene, in patients with major depressive disorder (n = 312) and panic disorder (n = 210), and matched healthy controls (n = 356). We found no significant associations of the SNPs in IL10 family genes with either diagnostic group. Haplotype analysis revealed seven haplotype blocks, but their frequencies did not differ between patients and controls. Significant associations were detected for SNP rs1539243 in IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) gene showing different allelic and genotypic distributions in the total as well as in separate diagnostic groups as compared to controls. IKBKE emerged as a candidate for further studies of genetic factors associated with panic disorder and major depressive disorder. |
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Keywords: | Single-nucleotide polymorphism (SNP) Major depressive disorder Panic disorder Case-control association study Interleukins Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE) |
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