Neighboring glycine residues are essential for P2X2 receptor/channel function |
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| Authors: | Ken Nakazawa Yasuo Ohno |
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| Affiliation: | Division of Pharmacology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo 158-8501, Japan |
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| Abstract: | The roles of a glycine-rich region in the cloned P2X2 receptor/channel were evaluated by site-directed mutagenesis. Responsiveness to ATP was lost when Gly247 was replaced by alanine. The sensitivity to ATP was reduced when Gly248 was replaced by alanine, and the responsiveness to ATP was lost when Gly248 was replaced by valine. The results suggest that the neighboring glycine residues are essential for P2X2 receptor/channel function. |
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| Keywords: | site directed mutagenesis purine p2x receptor amino acid |
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