针刺对肥胖大鼠瘦素和胰岛素含量的影响

目的 探讨针刺对肥胖机体瘦素(leptin)和胰岛素(INS)含量及其血脑转运的作用。方法 观察针刺治疗前后肥胖大鼠体质量、体脂及中枢和外周瘦素和INS水平的变化。结果 肥胖大鼠体质量、体脂及血清瘦素和INS水平均显著高于正常大鼠,而下丘脑瘦素和INS水平均显著低于正常大鼠。针刺治疗取得良好减肥疗效的同时,肥胖大鼠血清瘦素和INS水平均有明显降低,而下丘脑瘦素和INS水平却明显升高。结论 肥胖大鼠瘦素和INS血脑转运异常可能是产生瘦素抵抗(LR)和胰岛素抵抗(IR)的重要原因。针刺时肥胖机体下丘脑和血中瘦素和INS水平的良性调节作用可能是改善LR和IR以及调节异常内分泌代谢的一个重要环节。这种作用可能是针刺减肥的关键因素之一。

Effect of acupuncture on contents of leptin and insulin in obese rats

Objective It is to explore the effect of acupuncture on the contents and blood-brain transport of leptin and insulin is obese organism. Methods The changes of body weight, body fat, the levels leptin and insulin of central and peripheral in obese rats were observed before and after acupuncture. Results The body weight, body fat, the levels of serum leptin and insulin in the obese rats were all markedly higher than those in the normal rats, but the levels of hypothalamic leptin and insulin in obese rats were all lower than those of normal rats. After acupuncture treatment the marked weight losing effect was achieved while the levels of serum leptin and insulin obviously decreased, the levels of hypothalamic leptin and insulin obviously increased in obese rats. Conclusion The abnormal transport of blood-brain barrier of leptin and insulin may be an important factor for the resistance of leptin and insulin in obese rats. The good regulation of acupuncture on levels of hypothalamic and serum leptin and insulin possibly is an important link in improving the resistance of leptin and insulin as well as regulation abnormal metabolism in obese organism. The effective regulation is possibly the key factors in the anti-obesity of acupuncture.