Improvement of chemical instability of prostacyclin in aqueous solution by complexation with methylated cyclodextrins |
| |
| Affiliation: | 1. Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 51, Huayuan Bei Road, Beijing 100191, China;2. Beijing HuiLong Guan Hospital, Huilong guan Changping District, Beijing 100096, China;3. Shanghai Mental Health Center, 600, Wanpingnan Street, Shanghai 200030, China;4. West China Hospital of Sichuan, 37, Guoxue Street, Wuhou District, Chengdu, Sichuan 610041, China;5. Suzhou Guangji Hospital, 285, Guangji Street, Gusu District, Suzhou, Jiangsu 215008, China;6. Guangzhou Psychiatric Hospital, 36, Mingxin Street, Liwan District, Guangzhou, Guangdong 510000, China;7. The Seventh People''s Hospital of Hangzhou, 305, Tianmushan Street, Xihu District, Hangzhou, Zhejiang 310013, China;8. Jining Mental Hospital, 1, Jidai Street, Jining, Shandong 272000, China;9. Shenzhen Kangning Hospital, 1080, Cuizhu Street, Luohu District, Shenzhen 518003, China;10. Nanjing Brain Hospital, 264, Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China;11. Xijing Hospital of Forth Military Medical University, 15, Changlexi Road, Xi’an, Shanxi 710032, China;12. The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Tianhe District, Guangzhou, Guangdong 510630, China;13. Harbin First Specific Hospital, 217, Hongwei Road, Harbin, Heilongjiang 150056, China;14. Sixth Hospital of Changchun, 4596, Beihuan Road, Changchun, Jilin 130052, China;1. Department of Biosystems Engineering, Tarbiat Modares University, Tehran, Iran;2. Department of Biosystems Engineering, University of Tehran, Tehran, Iran;3. Mechanical Engineering Department, Eindhoven University of Technology, Eindhoven, the Netherlands;1. Guangdong Engineering Technology Research Center of Low Carbon and Advanced Energy Materials, Institute of Semiconductors, South China Normal University, Guangzhou 510631, China;2. School of Chemical Engineering and Energy Technology, Dongguan University of Technology, Dongguan 523808, China;3. Physics Department, University of Kotli Azad Kashmir Pakistan, Azad Kashmir 11100, Pakistan;4. SCNU Qingyuan Institute of Science and Technology Innovation Co., Ltd, Qingyuan 511517, China |
| |
| Abstract: | Effects of various methylated cyclodextrins on the hydrolysis rate of prostacyclin (PGI2) were investigated and compared with natural cyclodextrins (CyDs). All CyDs decelerated the hydrolysis of PGI2. Among them, heptakis (2.3-di-O-methyl)-β-cyclodextrin (DM-β-CyD) had a marked stabilization effect, by factors of about 30 and 10 at pHs 4.0 and 7.0. respectively. Analysis of the rate-pH profiles indicated that the ionization of the terminal carboxylic acid moiety of PGI2is suppressed upon binding to CyDs. Thermodynamic activation parameters suggested that the deceleration effect of CyDs generally resulted from the increase in the activation enthalpy term rather than the decrease in entropy term. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
