BMPER在卵巢浆液性肿瘤中的表达及临床意义

目的:检测BMPER在卵巢浆液性肿瘤组织中的表达，分析其与卵巢浆液性癌临床病理参数及预后的关系，探讨BMPER表达的临床意义。方法:应用免疫组织化学方法检测59例卵巢浆液性癌、21例卵巢浆液性交界性肿瘤、23例卵巢浆液性良性肿瘤和28例正常卵巢组织中BMPER的表达，分析其与卵巢癌患者临床病理参数及预后的关系。结果:BMPER主要以细胞浆和细胞间隙着色为主。BMPER在卵巢浆液性癌中表达的阳性率（89.83%）高于卵巢交界性肿瘤（76.19%）、卵巢良性肿瘤（39.13%）和正常卵巢组织（28.57%），与后两组相比P<0.01。淋巴结转移阳性及晚期卵巢癌患者的BMPER高表达率高于淋巴结转移阴性和早期患者（P<0.05）。Kaplan-Meier生存分析显示BMPER高表达组患者生存率明显低于低表达组。Cox回归分析显示BMPER高表达是患者不良预后的独立危险因素（P=0.025）。结论:BMPER在卵巢浆液性癌中高表达，与卵巢癌的不良预后密切相关，因此BMPER可能是一个潜在的预测卵巢癌预后的评价指标。

The expression and clinical significance of BMPER in serous ovarian tumors

Objective:To detect the expression of BMPER in ovarian serous tumor tissue samples and to analyze its relationship with the clinicopathological parameters and the prognosis of ovarian serous carcinoma.Methods:BMPER expression in 59 ovarian serous carcinoma,21 ovarian serous borderline tumor,23 ovarian serous benign tumor and 28 normal ovarian tissue samples were detected by immunohistochemistry.Its relationship with the clinicopathological parameters and the prognosis was analyzed.Results:BMPER was predominantly expressed in the cytoplasm and intercellular space. The positive rate of BMPER expression in the ovarian serous carcinoma(89. 83%) sampleswas substantially higher than those in the ovarian borderline tumor(76. 19%),ovarian benign tumor(39. 13%) andnormal ovarian tissue(28. 57%) samples,and there was significant difference compared with the latter two groups(P< 0. 01). The high expression rate of BMPER in the positive lymph node metastasis group and the advanced ovariancancer group was higher than that in the negative lymph node metastasis group and early stage group(P< 0. 05). Ka-plan-Meier(KM) survival analysis showed that the survival rate of patients with BMPER high expression was signif-icantly lower than that of patients in the low expression group. Cox regression analysis showed that BMPER high ex-pression was an independent risk factor of poor prognosis for patients(P= 0. 025).Conclusion:BMPER is highly ex-pressed in ovarian serous cancer and is closely correlated to the poor prognosis of ovarian cancer. Therefore,BMPER isa potential prognostic marker for ovarian cancer.