血清维生素水平与肺鳞癌转移特征的相关性

目的:检测并分析血清中九种维生素水平与肺鳞癌转移特征的关系。方法:回顾性分析2016年01月至2018年08月,就诊于我院的肺鳞癌患者,按照纳入及排除标准,共78例肺鳞癌患者纳入本研究,在初始抗肿瘤治疗时检测其血清中九种维生素水平,记录并比较血清中九种维生素水平在非转移组及转移组中分布特征;对肺鳞癌转移组进一步分析,按照转移部位及数目分为寡转移组与多发转移组,按照是否发生肝转移分为肝转移组与非肝转移组,比较血清维生素营养状态在肺鳞癌不同转移特征中的差异。结果:在肺鳞癌患者中,血清维生素营养状态水平在非转移组与转移组两组之间无统计学差异;对肺鳞癌转移组进一步分析,结果显示,寡转移组与多发转移组在血清维生素A、维生素D等方面存在差异,且具有统计学意义,而在维生素B族、维生素C、维生素E等方面无显著性差异;对于转移组中是否发生肝转移分组分析中,结果显示,肝转移组与非肝转移组,在维生素A、维生素B族等方面无差异,但在血清维生素D水平之间存在显著性差异。结论:对于肺鳞癌患者,血清维生素D水平在多发转移组中低于寡转移组,同时结果提示,对于伴有肝转移组,其血清维生素D水平亦低于非肝转移组;而对于肺鳞癌患者,发生多发转移与肝转移者具有更差预后,提示维生素D可能在肺鳞癌转移中起到一定抑制作用,对于肺鳞癌患者补充维生素D水平或许有助于抑制其转移,但限于为单中心研究,其结论有待进一步多中心研究证实。

Correlation between serum vitamin levels and metastatic characteristics of lung squamous cell carcinoma

Objective:The relationship between serum concentrations of nine vitamins and metastatic characteristics of lung squamous cell carcinoma was detected and analyzed,providing a theoretical basis for individualized guidance of certain vitamins and metastatic characteristics of lung squamous cell carcinoma.Methods:A retrospective analysis was conducted from January 2016 to August 2018.According to include and exclude standards,a total of 78 cases of new diagnosed lung squamous cell carcinoma were included in this study.The initial anti-tumor treatment testing serum levels of nine vitamins were measured.The differences between the two groups(non-metastatic group vs metastatic group)were compared and analysed.In addition,serum vitamin nutritional status was analysed in multiple metastatic group and oligo-metastatic group,also in liver-metastatic group and non-liver-metastatic group.Results:There was no significant difference in serum levels of 9 vitamins between the non-metastatic group and the metastatic group.Further analysis of lung squamous cell carcinoma in the metastatic group showed that there were significant differences in serum vitamin A and vitamin D between the oligo-metastatic group and the multi-metastatic group,but no significant differences in vitamin B group,vitamin C and vitamin E.The analysis of whether liver metastasis occurred in the metastatic group showed that there was no difference in vitamin A and vitamin B group between the liver metastatic group and the non-liver metastatic group,but there was a significant difference in serum vitamin D level.Conclusion:For patients with lung squamous carcinoma,serum vitamin D level in the group of multi-metastatic group was lower that in oligo-metastatic group,at the same time,the results suggest that for the liver metastatic group,the serum vitamin D level was lower than the non-liver metastasis group.For the lung squamous carcinoma patients,multiple metastases or liver metastasis have worse prognosis,suggesting that vitamin D might play an inhibitory role in lung squamous carcinoma metastasis,and for lung squamous carcinoma patients complement vitamin D level may help suppress the tumor metastasis,but limited to the single center study.The conclusion remains to be further studied.