| 3-磷酸甘油酸脱氢酶促进丝氨酸合成在肿瘤进展中的机制 |
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| 引用本文： | 崔畅婉,孙峥嵘. 3-磷酸甘油酸脱氢酶促进丝氨酸合成在肿瘤进展中的机制[J]. 现代肿瘤医学, 2021, 0(5): 885-888. DOI: 10.3969/j.issn.1672-4992.2021.05.037 |
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| 作者姓名： | 崔畅婉 孙峥嵘 |
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| 作者单位： | 中国医科大学附属盛京医院生物样本库,辽宁 沈阳 110001 |
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| 基金项目： | 国家自然科学基金(编号:81171581);辽宁省高等学校基本科研项目(编号:LFWK201710);辽宁省重点研发计划指导计划项目(编号:2018225009)。 |
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| 摘 要： | 丝氨酸生物合成途径活性的上调是许多癌症明显的共同特征.该途径的第一种限速酶3-磷酸甘油酸脱氢酶(PHGDH)在黑色素瘤、乳腺癌和肾癌等癌组织中高表达,对肿瘤细胞增殖、转移、侵袭有着重要作用.糖酵解中间产物3-磷酸甘油酸在PHGDH作用下,氧化为磷酸羟基丙酮酸并最终合成丝氨酸.丝氨酸转化为甘氨酸,然后在核苷酸、s-腺苷甲...
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| 关 键 词： | 3-磷酸甘油酸脱氢酶 肿瘤 糖酵解 |
The mechanism of 3-phosphoglycerate dehydrogenase promoting serine synthesis in tumor progression |
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| CUI Changwan,SUN Zhengrong. The mechanism of 3-phosphoglycerate dehydrogenase promoting serine synthesis in tumor progression[J]. Journal of Modern Oncology, 2021, 0(5): 885-888. DOI: 10.3969/j.issn.1672-4992.2021.05.037 |
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| Authors: | CUI Changwan SUN Zhengrong |
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| Affiliation: | Department of Biobank,Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110001,China. |
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| Abstract: | Upregulation of serine biosynthetic pathway activity is a distinct common feature of many cancers.3-phosphoglycerate dehydrogenase(PHGDH),the first rate-limiting enzyme in this pathway,is highly expressed in melanoma,breast and kidney cancer.PHGDH plays an important role in tumor cell proliferation,metastasis and invasion.Glycolysis intermediate product 3-glyceric acid phosphate oxidized to hydroxypropionic acid phosphate under PHGDH action,and finally synthesized serine.Serine converted to glycine and then plays an important role in the synthesis of nucleotides,s-adenosylmethionine(SAM) and reduced glutathione(GSH).PHGDH is expected to be a new target for tumor therapy. |
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| Keywords: | 3-phosphoglycerate dehydrogenase cancer glucolysis |
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