乳腺癌Hpa表达与淋巴管生成的相关性

目的 探讨乙酰肝素酶(Hpa)在乳腺正常组织、不典型增生、导管内癌、浸润性导管癌组织中的表达水平,分析其与浸润性乳腺癌临床病理指标及肿瘤淋巴管生成之间的关系.方法 收集西安交通大学第一附属医院2005年1月至2007年12月经手术切除的23例不典型增生组织,34例导管内癌组织,80例浸润性导管癌组织标本,以及距离肿瘤边...

Correlation between Heparanase expression and lymphangiogenesis in breast cancer

Objective To investigate the expression of Heparanase(Hpa)in normal breast tissue,atypical hyperplasia,intraductal carcinoma and invasive carcinoma,and to analyze the relationship between Hpa with clinicopathological factors and tumor lymphangiogenesis in breast cancer.Methods Twenty three cases of atypical hyperplasia tissues,34 cases of intraductal carcinoma tissues,80 cases of invasive ductal carcinoma tissue specimens,and 20 cases of normal breast tissues 5 cm away from the tumor edge after surgical removal were collected from the First Affiliated Hospital of Xi′an Jiaotong University between January 2015 and December 2007.The expressions of Hpa in different groups were detected by immunohistochemical method,and the relationship between Hpa expression and clinicopathological factors such as tumor diameter,axillary lymph node metastasis,pathological stage and expression of estrogen and progesterone receptor was analyzed.The lymphatic vessels were labeled with D2-40.The effect of Hpa expression on tumor lymphangiogenesis was analyzed.Results The positive rates of Hpa expression in normal breast tissue,atypical hyperplasia,intraductal carcinoma and invasive carcinoma were 15.0%,34.8%,52.9%and 76.3%,showed a gradually increasing trend(χ²=31.403,P<0.01).The positive expression rate of Hpa was statistically different between breast intraductal carcinoma and invasive carcinoma(χ²=6.093,P<0.05).There were significant differences in Hpa positive expression rate among groups of different clinical stages,lymph node metastasis and tumor diameter in invasive carcinoma(P<0.05).The MLD value of Hpa positive group was significantly higher than that of Hpa negative group in invasive carcinoma(9.961±4.329 vs 7.339±3.714,t=2.379,P<0.05).There was a positive correlation between Hpa expression and MLD(r=0.603,P<0.05).Conclusions Hpa is highly expressed in invasive breast cancer,and its upregulation is related to lymphangiogenesis.