| MLLT3在急性白血病中的研究进展 |
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| 引用本文： | 张鑫宇,吕涵柠,赵文浩,孙立春. MLLT3在急性白血病中的研究进展[J]. 现代肿瘤医学, 2021, 0(6): 1079-1082 |
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| 作者姓名： | 张鑫宇 吕涵柠 赵文浩 孙立春 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院 |
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| 摘 要： | MLLT3是识别组蛋白共价修饰的染色质结合蛋白模块和超伸长复合物的关键组分,通过组蛋白修饰在调节染色质重塑和许多重要原癌基因的表达中发挥关键作用.并且,MLLT3易位产生MLL-MLLT3融合基因导致急性白血病.在本综述中,我们总结了MLLT3分子的结构和功能、MLLT3的生理作用、MLLT3在急性白血病发生发展中的病...
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| 关 键 词： | MLLT3 MLL-MLLT3易位 急性白血病 |
Advances of researches on the role of MLLT3 in acute leukemia |
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| ZHANG Xinyu,LYU Hanning,ZHAO Wenhao,SUN Lichun. Advances of researches on the role of MLLT3 in acute leukemia[J]. Journal of Modern Oncology, 2021, 0(6): 1079-1082 |
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| Authors: | ZHANG Xinyu LYU Hanning ZHAO Wenhao SUN Lichun |
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| Affiliation: | (Harbin Medical University Cancer Hospital,Heilongjiang Harbin 150081,China) |
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| Abstract: | MLLT3 is a histone covalent modifications by chromatin-binding protein modules and a critical component of the super elongation complex.In addition,MLLT3 plays pivotal roles in the regulation of chromatin remodelling and gene expression of many important proto-oncogenes via histone modification.MLLT3 translocation into the MLL-MLLT3 fusion gene contributes to acute leukemia.In this review,we have summarized what is currently known about the structure and function of the MLLT3 molecule.We described the physiological role of MLLT3 and the pathological effects on the development of acute leukemia,as well as the emerging knowledge of MLLT3 as an epigenetic therapeutic target,providing new ideas for the diagnosis and treatment of acute leukemia. |
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| Keywords: | MLLT3 MLL-MLLT3 translocation acute leukemia |
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