| 正交试验优选逐瘀止痛凝胶膏剂的水提工艺研究 |
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| 引用本文： | 杨东,毕建云,郭艳伟,张震宇. 正交试验优选逐瘀止痛凝胶膏剂的水提工艺研究[J]. 药学实践杂志, 2017, 35(2): 146-149 |
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| 作者姓名： | 杨东 毕建云 郭艳伟 张震宇 |
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| 作者单位： | 潍坊市益都中心医院, 山东 潍坊 262500;长春中医药大学, 吉林 长春 130117,山东中医药大学, 山东 济南 250355,潍坊市益都中心医院, 山东 潍坊 262500,山东中医药大学, 山东 济南 250355 |
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| 基金项目： | 山东中医药大学教育科学研究实验教学专项（sy2016021） |
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| 摘 要： | 目的 优选逐瘀止痛凝胶膏剂的水提工艺。方法 以赤芍中的芍药苷得率及干膏得率为考察指标，在单因素实验的基础上，采用正交设计优选出逐瘀止痛凝胶膏剂水提取工艺。结果 优选出的水提工艺为：浸泡1 h，加8倍量水（第2、3次加8倍水），回流提取3次，每次1.5 h。结论 该提取工艺科学合理、稳定可行，可用于逐瘀止痛凝胶膏剂的工业化生产。
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| 关 键 词： | 逐瘀止痛 凝胶膏剂 芍药苷 正交试验 |
| 收稿时间： | 2016-12-28 |
| 修稿时间： | 2017-01-18 |
Optimization of the water extraction process for Zhuyu Zhitong gel paste by orthogonal experiment |
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| YANG Dong,BI Jianyun,GUO Yanwei and ZHANG Zhenyu. Optimization of the water extraction process for Zhuyu Zhitong gel paste by orthogonal experiment[J]. The Journal of Pharmaceutical Practice, 2017, 35(2): 146-149 |
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| Authors: | YANG Dong BI Jianyun GUO Yanwei ZHANG Zhenyu |
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| Affiliation: | Yidu Central Hospital of Weifang, Weifang 262500, China;Changchun University of Traditional Chinese Medicine, Changchun 130117, China,Shandong University of Traditional Chinese Medicine, Jinan 250355, China,Yidu Central Hospital of Weifang, Weifang 262500, China and Shandong University of Traditional Chinese Medicine, Jinan 250355, China |
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| Abstract: | Objective To study the water extraction process of Zhuyu Zhitong gel paste.Methods With the yields of paeoniflorin and the dry paste as target, the water extraction process of Zhuyu Zhitong gel paste was optimized by an orthogonal experimental design based on the single factor experiment.Results The optimized water extraction process of Zhuyu Zhitong gel paste was soaking the materials for 1 h with 8 times of water, then extracting 1.5 h for three times with the same amount of water.Conclusion The optimized extraction process was consistent, reasonable and feasible for large production. |
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| Keywords: | Zhuyu Zhitong gel paste paeoniflorin orthogonal experiment |
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