冠心病患者血清GGT、血脂、hs-CRP联合检测的临床价值

目的 探讨血清谷氨酰转肽酶（GGT）、血脂、超敏C反应蛋白（hs-CRP）联合检测在冠心病患者临床诊断中的价值。方法 选择入院期间行冠脉造影术后确诊的冠心病患者134例，非冠心病对照组38例。冠心病患者根据Gensini评分分为冠状动脉轻度狭窄组（A组）40例、中度狭窄组（B组）38例、重度狭窄组（C组）56例。检测各组患者年龄、性别、血清GGT、血脂、hs-CRP水平。结果 冠心病组血清血清GGT、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、hs-CRP水平均高于非冠心病组（P < 0.05），冠心病组高密度脂蛋白（HDL）低于非冠心病组（P < 0.05）。B、C组血清GGT、TC、TG、LDL、hs-CRP水平均高于A组（P < 0.05），B、C组血清HDL低于A组（P < 0.05）。C组血清GGT、TC、TG、LDL、hs-CRP水平均高于B组（P < 0.05），C组血清HDL低于B组（P < 0.05）。Logistic回归分析显示血清GGT、TG、hs-CRP是冠心病的独立危险因素（P < 0.05），HDL是冠心病的独立保护因素（P < 0.05）。结论 GGT、血脂、hs-CRP的联合检测在冠心病的诊断中具有重要价值。

Clinical Value of Combined Detection of GGT, Serum Lipids and hs-CRP in Patients with Coronary Heart Disease

Objective To investigate the value of combined detection of GGT, blood lipid and hs-CRP in patients with coronary heart disease. Methods Totally 134 patients with coronary heart disease and 38 patients without coronary heart disease were selected after coronary angiography.Coronary heart disease patients were divided into mild stenosis group(group A,n=40), Moderate stenosis group (group B,n=38) and severe stenosis group (group C,n=56) according to Gensini score. The age, sex,GGT, blood lipid and hs-CRP levels were detected in all groups, and t-he statistical analysis was performed by using SPSS 22.0 software. Results The level of GGT, TC, TG, LDL and hs-CRP in CHD group were all higher than those in non CHD group (P < 0.05).The level of HDL was lower than that in the non CHD group (P < 0.05).The level of GGT, TC, TG, LDL,hs-CRP in group B and C were higher than group A(P < 0.05).The level of HDL in group B and C were lower than group A(P < 0.05).The level of GGT,TC, TG, LDL, hs-CRP in group C were higher than group B(P < 0.05).Logistic regression analysis showed that serum GGT,TG,hs-CRP were independent risk factors for coronary heart disease(P < 0.05), HDL was an independent protective factor for coronary heart disease(P < 0.05). Conclusion The combined detection of GGT, blood lipid and hs-CRP has important value in the diagnosis of coronary heart disease.