| 高纯度单体制备及结构鉴定芹菜籽中3种苯酞成分 |
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| 引用本文： | 陈雯慧,沈刚,陈海生. 高纯度单体制备及结构鉴定芹菜籽中3种苯酞成分[J]. 药学实践杂志, 2017, 35(2): 138-140 |
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| 作者姓名： | 陈雯慧 沈刚 陈海生 |
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| 作者单位： | 第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433,第二军医大学药学院天然药物化学教研室, 上海 200433 |
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| 基金项目： | 上海市中药现代化专项资助（09dZ1974000） |
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| 摘 要： | 目的 分离和鉴定芹菜籽中苯酞类化合物。方法 采用硅胶柱色谱、制备薄层色谱方法分离纯化苯酞类化学成分，用波谱分析技术鉴定化合物结构。结果 从芹菜籽中分离制备得到3种主要的苯酞类化合物，分别鉴定为芹菜甲素、芹菜乙素和新蛇床内酯。结论 采用该法制备的样品纯度大于98%，可作为对照品使用。
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| 关 键 词： | 芹菜籽 芹菜甲素 芹菜乙素 新蛇床内酯 结构鉴定 |
| 收稿时间： | 2016-06-15 |
| 修稿时间： | 2016-08-22 |
High purity preparation and identification of three phthalide compounds from Apium graveolens |
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| CHEN Wenhui,SHEN Gang and CHEN Haisheng. High purity preparation and identification of three phthalide compounds from Apium graveolens[J]. The Journal of Pharmaceutical Practice, 2017, 35(2): 138-140 |
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| Authors: | CHEN Wenhui SHEN Gang CHEN Haisheng |
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| Affiliation: | Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China,Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China and Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Objective Isolation, purification and structure identification of phthalides from Apium graveolens L.Methods Silica gel column and preparative TLC chromatography were used to isolate and purify the phthalide compounds. The structures of those compounds were determined through spectral analysis.Results Three pure compounds were identified as 3-n-butylphthalide, sedanenolide and sedanolide.Conclusion Three pure phthalide compounds can be used as analytical reference standard for quantitative analysis of A. graveolens. |
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| Keywords: | Apium graveolens 3-n-butylphthalide sedanenolide sedanolide structure identification |
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