| 有机阳离子转运体的基因多态性研究进展 |
| |
| 引用本文： | 韩林志,周宏灏. 有机阳离子转运体的基因多态性研究进展[J]. 中国临床药理学与治疗学, 2009, 14(4): 460-465 |
| |
| 作者姓名： | 韩林志 周宏灏 |
| |
| 作者单位： | 中南大学临床药理研究所,湖南长沙410008 |
| |
| 摘 要： | 人体的肝脏、肾脏和肠道上广泛分布有各种转运蛋白，其中有机阳离子转运体（OCTs）负责转运一些内、外源性的有机阳离子的转运。在此我们主要讨论的是OCTs家族的成员OCT1和OCT2的基因多态性以及其功能意义。同时我们也就OCT对于药物代谢动力学以及药效学的影响进行阐述，以及OCTs在药物相互作用上的意义。
|
| 关 键 词： | 有机阳离子转运体 基因多态性 药代动力学 |
Development of the genetic polymorphism study on organic cation transporters |
| |
| HAN Lin-zhi,ZHOU Hong-hao. Development of the genetic polymorphism study on organic cation transporters[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 460-465 |
| |
| Authors: | HAN Lin-zhi ZHOU Hong-hao |
| |
| Affiliation: | (Institute of Clinical Pharmacology, Central South University, Changsha 410008, Hunan, China ) |
| |
| Abstract: | Various kinds of transporters exist in human organs, such as liver, kidney and intestine. The transport of cationic substrates which include endogenous metabolites, exotic substance, and drugs was mainly executed by different organic cation transporters (OCTs) . In this article the genetic polymorphisms and their influences on OCTs funtions were mainly reviewed. Meanwhile, the recent findings of OCTs polymorphism influences on pharmacodynamics and phar-macokinetics value of several clinical widely used drugs were also included in this review. |
| |
| Keywords: | organic cation transporter genetic polymorphism pharmacokinetics |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
