Assessment of soluble intracellular adhesion molecule-1 (sICAM-1) in women with benign ovarian tumors |
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Authors: | Rzymski Paweł Opala Tomasz Woźniak Jakub Drews Krzysztof Sajdak Stefan |
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Institution: | Klinika Zdrowia Matki i Dziecka AM w Poznaniu, Poznań. parzymsk@gpsk.am.poznan.pl |
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Abstract: | OBJECTIVES: Overexpression of intracellular adhesion molecule-I (ICAM-1) was observed in many benign and malignant tumors. The aim of our study was to evaluate its serum concentrations as well as CA-125 in women with benign ovarian tumors. MATERIALS AND METHODS: Forty-five women treated surgically because of benign ovarian mass. RESULTS: Mean concentrations of sICAM-1 in benign tumors was 241.8+/-74.1 ng/ml and 195.6+/-68.7 ng/ml in healthy controls. No correlations between sICAM-1 concentrations and leukocyte count, tumor volume, BMI and obstetrical history. Efficiency in tumor differentiation was higher for CA-125 than sICAM-1 (area under Receiver Operating Characteristic curve 0.78 and 0.63 respectively). We observed higher sICAM-1 concentrations in fibrothecomas and lower in endometrial and dermoid cysts. CONCLUSIONS: Serum ICAM-1 concentrations correlate with some histological types of benign tumors, but not with tumor volume. Levels of CA-125 are more effective than ICAM-1 in ovarian tumors differentiation. |
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