| 乙型肝炎病毒pX与Bcl-2在肝癌中的表达 |
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| 引用本文： | 蒋向荣,王小众,陈晓春,陈治新.乙型肝炎病毒pX与Bcl-2在肝癌中的表达[J].中西医结合肝病杂志,2002,12(2):68-70. |
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| 作者姓名： | 蒋向荣 王小众 陈晓春 陈治新 |
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| 作者单位： | 福建医科大学附属协和医院,福州,350001 |
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| 基金项目： | 福建省科技课题(99-Z-162) |
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| 摘 要： | 目的:探讨肝癌组织中乙型肝炎病毒pX与BCl-2的表达状况及关系。方法:病理证实的34例肝癌组织经连续切片,常规脱蜡水化,用S-P法行pX与Bel-2免疫组织化学染色。结果:pX与Bcl-2在肝癌表达的阳性率分别为97.06％及17.65％。Redit分析示两组有显著差异(P<0.01),阳性信号均主要位于胞浆,且两者可在同一癌组织的相同区域出现阳性染色。结论:乙型肝炎病毒pX在肝癌组织中存在高强度的广泛表达,pX的表达可能具有激活Bcl-2抑制癌细胞凋亡的作用。
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| 关 键 词： | 乙型肝炎病毒 X蛋白 Bcl-2 肝癌 |
| 修稿时间： | 2002年1月29日 |
Expression of HBV pX and Bcl-2 in Patients with Hepatocellular Carcinoma |
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| JIANG Xiangrong,WANG Xiaozhong,CHEN Xiaochun,et at.Expression of HBV pX and Bcl-2 in Patients with Hepatocellular Carcinoma[J].Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases,2002,12(2):68-70. |
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| Authors: | JIANG Xiangrong WANG Xiaozhong CHEN Xiaochun et at |
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| Institution: | JIANG Xiangrong,WANG Xiaozhong,CHEN Xiaochun,et at. Department of Gastroenterology,Union Hospital Fujian Medical University |
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| Abstract: | Objective: To assess the expression of HBV pX and Bcl-2 in patients with hepatocellular carcinoma. Methods: Tissues from 34 patients with hepatocellular carcinoma were diagnosed by pathology. With successive section and dewaxing, the expression of pX and Bcl-2 were tested by using SP assay. Results: The positive expression of pX and Bcl-2 in carcinoma tissues was 97. 06% and 17. 65%. Redit analysis showed that there was significant difference between these two groups (P<0. 01). The positive signal was mainly presented in the plasma, and the positive stainning of pX and Bcl-2 may appear in the same area. Conducsions: The pX was extensively and strongly expressed in the tissue of hepatocellular carcinoma and the abnomal expression of pX may promote the function of Bcl-2 in inhibition the apoptosis of the cancer cells. |
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| Keywords: | HBV X Protein Bcl-2 Hepatocellular Carcinocna |
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