Effect of a natural flavonoid on gastric mucosal barrier |
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| Authors: | A Cristoni S Malandrino M J Magistretti |
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| Affiliation: | Research and Development Laboratories, Inverni della Beffa, S.p.A., Milan, Italy. |
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| Abstract: | The effects of 3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-1-benzopyrylium chloride (IdB 1027) on the rat gastric mucosa were evaluated. IdB 1027 administered intragastrically at doses ranging from 100 to 400 mg/kg inhibited the fall in transmucosal potential difference and the increase in H+ back-diffusion induced by acetylsalicylic acid. Moreover, IdB 1027 at doses of 50 and 200 mg/kg by intragastric route increased the gastric bicarbonate secretion. These results suggest that the gastroprotective activity of IdB 1027 is mediated by an increase in the efficiency of gastric mucosal barrier. |
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