白藜芦醇对小鼠的急性经口毒性和遗传毒性试验研究

目的：了解白藜芦醇的急性经口毒性和遗传毒性,为白藜芦醇的食用、药用安全性评价提供实验依据。方法：按照《GB 15193-2003食品安全性毒理学评价程序和方法》的规定,对白藜芦醇进行急性经口毒性测定,并通过Ames试验（每皿分别加入5000、1000、200、40、8μg白藜芦醇）、小鼠骨髓嗜多染红细胞微核试验及小鼠精子畸形试验（分别以7.500、3.750、1.875g/kg剂量的白藜芦醇给小鼠灌胃）对其遗传毒性进行评价。结果：白藜芦醇的急性经口最大耐受剂量〉15.0g/kg;3项遗传毒性试验结果均为阴性。结论：在本实验条件下,白藜芦醇对小鼠的急性经口毒性属无毒,未见遗传毒性作用。

Study on the acute toxicity and genetic toxicity of resveratrol

OBJECTIVE:To determine the acute oral toxicity and genetic toxicity of resveratrol(Res),so to provide experimental basis for its application.METHODS:Acute oral toxicity test was performed in mice.The genetic toxicity of Res was evaluated by Ames test(Res doses at 5000,1000,200,40,8μg each dish),bone marrow micronucleus test and sperm shape abnormality test(Res was administered to mice at 7.500,3.750,1.875 g/kg doses). RESULTS:The acute oral maximum-tolerated dose(MTD)of resveratrol was greater than 15.0 g/kg.Ames test,micronucleus test and sperm shape abnormality test showed negative results.CONCLUSION:In our experimental context,resveratrol was classified as non-toxic substance.It did not produce genetic toxicity.