| 芪棱汤对大鼠脑缺血再灌注后兴奋性氨基酸的影响 |
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| 引用本文： | 邓世芳,蒋红玉,张思为,曹平. 芪棱汤对大鼠脑缺血再灌注后兴奋性氨基酸的影响[J]. 中国中医急症, 2011, 20(4): 585-586 |
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| 作者姓名： | 邓世芳 蒋红玉 张思为 曹平 |
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| 作者单位： | 1. 广东省深圳市人民医院,广东,深圳,518000
2. 广东省深圳市龙岗区人民医院,广东,深圳,518000 |
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| 基金项目： | 国家中医药管理局科研资助项目，广东省深圳市科技计划重点项目 |
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| 摘 要： | 目的观察芪棱汤对脑缺血再灌注损伤后兴奋性氨基酸（EAA）的影响,为益气养阴活血法治疗缺血性中风提供实验依据。方法将大鼠随机分为假手术组、模型组、补阳还五汤组及芪棱汤组。采用颈内动脉线栓加环扎法复制大鼠脑缺血再灌注模型。于再灌注后不同时间段观察大鼠缺血脑组织的谷氨酸（Glu）、门冬氨酸（Asp）的含量。结果模型组再灌注后各时间段的Glu含量及再灌注后24h段的Asp含量较假手术组显著减少,补阳还五汤组在再灌注24h段的Glu含量较模型组升高,芪棱汤组在再灌注24h段的Glu、Asp含量较模型组均明显升高,且芪棱汤组在再灌注24h段升高Glu、Asp方面优于补阳还五汤组。结论芪棱汤可降低EAA的神经毒性,从而对脑缺血再灌注所导致的脑损伤起保护作用。
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| 关 键 词： | 脑缺血再灌注 芪棱汤 益气养阴活血 兴奋性氨基酸 |
Influence of Qileng Decoction on Expression of Excitatory Amino Acid After Focal Cerebral Ischemic Reperfusion in Rats |
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| DENG Shi-fang,JIANG Hong-yu,ZHANG Si-wei,et al Shenzhen People''s Hospital,Guangdong Province. Influence of Qileng Decoction on Expression of Excitatory Amino Acid After Focal Cerebral Ischemic Reperfusion in Rats[J]. Journal of Emergency in Traditional Chinese Medicine, 2011, 20(4): 585-586 |
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| Authors: | DENG Shi-fang JIANG Hong-yu ZHANG Si-wei et al Shenzhen People''s Hospital Guangdong Province |
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| Affiliation: | DENG Shi-fang,JIANG Hong-yu,ZHANG Si-wei,et al Shenzhen People's Hospital,Guangdong Province(Shenzhen 518020,Guangdong) |
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| Abstract: | Objective:To explore the influence of Qileng Decoction on expression of excitatory amino acid after focal cerebral ischemic reperfusion in rats and to provide the scientific foundation for benefiting vital energy,nourishing yin and activating blood circulation on ischemic stroke.Methods:The rats were randomly divided into 4 groups including the sham-operation,the model group,the Buyanghuanwu Decoction group and the Qileng Decoction group.The model of focal cerebral ischemic reperfusion injury was made by us... |
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| Keywords: | Cerebral ischemic reperfusion Qileng Decoction Benefiting vital energy nourishing yin and activating blood circulation Excitatory amino acid |
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