| RP-HPLC法测定马来酸氟吡汀胶囊的含量 |
| |
| 引用本文： | 汪海洋,张延岭,聂磊.RP-HPLC法测定马来酸氟吡汀胶囊的含量[J].齐鲁药事,2010,29(10):595-597. |
| |
| 作者姓名： | 汪海洋 张延岭 聂磊 |
| |
| 作者单位： | 1. 山东大学药学院,山东,济南,250012;山东省医学科学院药物研究所,山东,济南,250062
2. 山东大学药学院,山东,济南,250012 |
| |
| 摘 要： | 目的建立反相高效液相色谱法测定马来酸氟吡汀胶囊中马来酸氟吡汀含量的方法。方法采用phenomenexC18柱(250mm×4.6mm,5μm),流动相组成为甲醇-水-甲酸(50∶50∶1),流速0.5mL.min-1,检测波长为347nm,进样量为20μL,。结果马来酸氟吡汀的浓度在36.36~84.84μg.mL-1范围内线性关系良好,相关系数r=1.0000。平均回收率为99.86%,RSD为0.74%。结论本法简便、快捷、准确,可用于马来酸氟吡汀胶囊中马来酸氟吡汀的含量测定。
|
| 关 键 词： | 高效液相色谱法 马来酸氟吡汀 含量测定 |
Determination of Flupirtine Maleate Capsules by RP-HPLC |
| |
| WANG Hai-yang,ZHANG Yan-ling,NIE Lei.Determination of Flupirtine Maleate Capsules by RP-HPLC[J].qilu pharmaceutical affairs,2010,29(10):595-597. |
| |
| Authors: | WANG Hai-yang ZHANG Yan-ling NIE Lei |
| |
| Institution: | 1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012;2.Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062) |
| |
| Abstract: | OBJECTIVE To establish a method for determination of flupirtine maleate in Flupirtine Maleate Capsules by RP-HPLC.METHODS The RP-HPLC analysis used phenomenex C18（250mm×4.6mm,5μm）as analysis column and the mobile phase was methanol-water-formic acid（50∶50∶1） with the flow rate of 0.5mL·min^-1.The detection wavelength was 347nm.The sample size was 20μL.RESULTS The linear range of flupirtine maleate was 36.36～84.84μg·mL^-1,r=1.0000.The average recovery was 99.86%,The RSD was 0.74%.CONCLUSION The method was simple,rapid,accurate and can be used to determine the flupirtine maleate in Flupirtine Maleate Capsules. |
| |
| Keywords: | RP-HPLC Flupirtine Maleate Determination |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
