糖化血红蛋白与血糖、血脂及心电图异常的相关性分析

目的探讨糖化血红蛋白（HbA1c）与血糖、血脂及心电图异常的关系,借以揭示血糖对动脉粥样硬化的影响。方法根据1999年WHO糖尿病的诊断标准和408例受检者的体检结果 ,将受检者分成血糖正常组和糖代谢异常组,根据糖化血红蛋白的水平,将糖代谢异常组分为A、B、C三组,即HbA1c〈6.5%（A组）、6.5%≤HbA1c〈8.0%（B组）、HbA1c≥8.0%（C组）,糖代谢异常组为分析组,血糖正常组为对照组。将各项检测指标分别在组内（分析组的A、B、C）和组间（分析组、对照组）进行比较。结果组内比较HbA1c、空腹血糖（FBG）、餐后2 h血糖（PBG）、总胆固醇（CHOL）以及心电图异常发生率,各项在A组与B组间、B组与C组间、A组与C组间差异均具有统计学意义（P〈0.05）,甘油三酯（TG）在组内比较差异无统计学意义（P〉0.05）,高密度脂蛋白（HDL-C）在A组与B组间差异具有统计学意义（P〈0.05）,低密度脂蛋白（LDL-C）在A组与B组间差异无统计学意义（P〉0.05）,在B组与C组间差异具有统计学意义（P〈0.05）。分析组和对照组比较,HbA1c、FBG、PBG、HDL-C、CHOL、TG以及心电图异常发生率各项差异均具有统计学意义（P〈0.05）。结论血糖升高可导致血脂异常,从而导致动脉粥样硬化,血糖升高可产生＂代谢记忆效应＂,应该重视血糖监测以便尽早发现糖代谢异常而进行尽早干预,以减少糖尿病和动脉粥样硬化的发生。

Correlation analysis of glycosylated hemoglobin,blood glucose,blood lipid and electrocardiographic abnormality

Objective To investigate the relationship between glycosylated hemoglobin （HbAlc）, blood glucose, blood lipid and electrocardiographic abnormality, in order to reveal the influence of blood glucose on atherosclerosis. Methods According to the 1999 WHO diagnostic criteria for diabetes and the results of physical examination of 408 subjects, the subjects were divided into normal blood glucose group and abnormal glucose metabolism group. According to the level of HbAlc, the abnormal glucose metabolism group was divided into three groups as group A, group B, and group C, they were HbAlc〈6.5% （group A）, 6.5% ≤ HbAlc〈8.0% （group B）, HbAlc ≥ 8.0% （group C）. Abnormal glucose metabolism group was the analysis group, and normal blood sugar group was the control group. The test indices were compared respectively in the group （group A, B and C in the analysis group）, and between groups （analysis group and control group）. Results Comparison of HbAlc, fasting blood glucose （FBG）, 2 h postprandial blood glucose （PBG）, cholesterol （CHOL） and electrocardiographic abnormality in the analysis group showed that all differences between group A and group B, group B and group C, group A and group C had statistical significance （P〈0.05）. There was no significant difference of triglyceride （TG） in the analysis group （P〉O.05）. The difference of high-density lipoprotein cholesterol （HDL-C） between group A and group B was statistically significant （P〈0.05）, and the difference of low-density lipoprotein cholesterol between the group A and group B had no statistical significance （P〉0.05）. The differences between group B and group C were statistically significant （P〈0.05）. The comparison between the analysis group and the control group showed that the differences of HbAlc, FBG, PBG, HDL-C, CHOL, TG, and electrocardiographic abnormality were all statistically significant （P〈0.05）. Conclusion Elevated blood glucose can lead to dyslipidemia and atherosclerosis