铜绿假单胞菌临床分离株耐药谱变迁分析

目的调查铜绿假单胞菌临床分离株近年来耐药谱的变迁,为临床合理选用药物提供依据。方法应用回顾性调查方法,对临床5年送检标本中分离的361株铜绿假单胞菌药敏试验进行统计分析。结果铜绿假单胞菌对阿米卡星、亚胺培南、头孢他啶、头孢哌酮/舒巴坦、头孢吡肟、环丙沙星、哌拉西林的敏感率约为70%;对复方磺胺、头孢噻肟、头孢曲松的敏感率最低,约10%,铜绿假单胞菌对常用的15种抗生素的耐药率呈上升趋势。结论铜绿假单胞菌对常用抗菌药物的耐药率高,多重耐药现象严重,根据药敏结果选择单一或联用抗菌药物,可有效控制和减缓细菌耐药性的增长。

Analysis on Vicissitudes of Drug Resistance Pattern in Clinically Isolated Strains of Pseudomonas Aeruginosa

Objective To investigate the vicissitudes of drug resistance pattern in clinically isolated strains of pseudomonas aeruginosa during recent years,in order to provide the basis for rational use of drugs.Method Retrospective study was applied to analyze the drug sensitivity of 361 strains of P.aeruginosa isolated from clinical specimens dring last 5 years.Results The sensitive rate of P.aeruginosa to Amikacin,Imipenem,Ceftazidime,Cefoperazone/Sulbactam,Cefepim,Ciprofloxacin,Piperacillin was about 70%.Its sensitive rate to compound sufamethoxazole tablets,cefotaxime,ceftriaxone was the lowest(only 10%).Its resistant rate to 15 kinds of common antibiotics tended to rise.Conclusions The resistance rates of P.aeruginosa to common antibiotics are high and the resistance pattern is wide.Choosing single or combinative antibiotic according to the results of drug sensitivity could control and slow down the increment of bacterial drug resistance.