左旋门冬酰胺酶对儿童急性淋巴细胞白血病和非霍杰金淋巴瘤胰腺功能的影响

 目的 观察左旋门冬酰胺酶（L-ASP）对儿童急性淋巴细胞白血病和非霍杰金淋巴瘤胰腺功能的影响。方法 VDLP方案治疗136例患儿,观察L-ASP使用前后血、尿淀粉酶,血脂肪酶,血、尿糖,尿酮体变化情况。结果 发生不良反应12例,其中急性胰腺炎（AP）5例,高血糖、糖尿病5例,急性胰腺炎＋高血糖2例。结论 急性胰腺炎、高血糖为L-ASP使用时胰腺副作用的主要表现形式,与患儿年龄、性别相关,严重时可危及生命,须引起高度重视。

Toxicity of L-asparaginase to Pancreas in Childhood Acute Lymphoblastic Leukemia and Non-hodgkin''''s Lymphoma

Objective To observe the toxicity of pancreas from L-asparaginase in childhood ALL and NHL.Methods One hundred and thirty-six cases ALL and NHL were treated with VDLP protocol.Their Amylase and glucose in blood and urine and lipase were inspected regularly.Results Twelve cases got toxicity on pancrease, 5 cases got acute pancreatitis and 5 had hyperglycemia; 2 cases got the both.Conclusion Acute pancreatitis and hyperglycemia are serious damage of the pancreas caused by L-ASP and may be related to the patients'age and the sex. Acute pancreatitis and hyperglycemia must be paid enough attention.