川芎嗪对严重烫伤豚鼠早期血浆心钠素含量变化的影响

目的　观察严重烫伤豚鼠早期血浆心钠素的含量变化及川芎嗪对其影响。方法　复制 3 0 %TBSA三度烫伤动物 (豚鼠 )模型 ,随机分成复苏组和川芎嗪治疗组 ,每组均在烫伤后 2 ,4,8,12 ,2 4,48h六个时相点 ,抽腹腔静脉血2 -3ml ,用放射免疫法测定血浆ANP浓度。另设正常对照组。结果　两组血浆ANP均在伤后 2h显著升高 (P <0 .0 1) ,4h后开始下降 ,8-2 4h下降显著 (P <0 .0 5 ) ,48h后又开始回升 ;但治疗组从 4h后含量明显高于复苏组。结论　烫伤豚鼠早期血浆ANP分泌量降低 ,中药川芎嗪可促进ANP的分泌。提示重度烧伤早期应用中药川芎嗪有重要的临床价值。

The change in the plasma contents of ANP and the effects of TMP on it during the early postburn stage in severely scalded Guinea-pigs

Objective To observe the change in the plasma contents of ANP and the effects of TMP on it during the early postburn stagein severely scalded Guinea-pigs. Methods To duplicate severely scalded animal model(30% TBSAⅢ°). The animals were divided into two groups: fluid replaced group and Tetramethylpyraxin (TMP) group, and set up normalcontrol group additionally. To collect blood sample after postburn (PB) 2,4,8,12,24 and 48h, to measure the content of plasma ANP by radioimmunoassay (RIA). Results during burn early stage the level of plasma ANP elevated significantly at 2h ( P <0.01), then decline at 4h and decrease significantly at 8-24h, begin to rise at 48 h. Compared with fluid replaced group, the decline of ANP was lightened in TMP group, there was significance at 8,12 and 24h( P <0.05). Conclusion The release of ANP decreaseduring the early postburn stage. TMP may stimulate release of ANP. It implies that TMP has important clinical value on the severe burn therapy.