| 创伤性脑损伤后动态CT灌注像的实验研究 |
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| 引用本文： | 刘科,唐文渊. 创伤性脑损伤后动态CT灌注像的实验研究[J]. 第三军医大学学报, 2008, 30(13): 1299-1302 |
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| 作者姓名： | 刘科 唐文渊 |
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| 作者单位： | 重庆医科大学附属第一医院神经外科,重庆,400016;重庆市急救医疗中心神经外科,重庆,400014;重庆医科大学附属第一医院神经外科,重庆,400016 |
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| 摘 要： | 目的 采用64排螺旋CT对创伤性脑损伤大鼠进行动态灌注扫描,以了解脑损伤后局部脑灌注改变.方法 45只成熟雄性SD大鼠分为3组:正常对照组、假手术组和实验组.3组均于大鼠脑损伤模型建立后1 h、6 h、24 h、3 d、7 d、14d、21 d分别行头颅CT灌注像(CT perfusion,CTP)扫描.选取伤侧损伤灶周围2 mm内及健侧镜像区为观察兴趣区.CTP后取脑做脑损伤区域石蜡固定切片,在光镜下观察大脑皮层损伤区的病理改变.结果 创伤后1 h损伤局部就有明显的脑血流量(cerebral blood flow,CBF)和脑血容量(cerebral blood volume,CBV)降低.伤后24 h CBF、CBV开始增高,伤后3 d时达到高峰;伤后14 d二者基本恢复正常.呈现损伤灶局部早期低灌注(1 h左右),随后呈现高灌注(6 h至7 d),晚期脑灌注倾于正常的动态脑血液动力学变化.健侧CBF在伤侧CBF伤后3 d明显增高时则呈下降趋势,而健侧CBV与正常组比较没有明显改变增高,反映了健侧完善的脑血管的自动调节功能.结论 对创伤性脑损伤行动态CTP能够了解脑损伤后的血液流变学规律和脑血管的自动调节机制,为脑外伤后继发性脑损害的救治提供有针对性的实验研究基础.
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| 关 键 词： | 创伤性脑损伤 CT灌注像 血液动力学 大鼠 |
Experimental study on hemodynamics of traumatic brain injury using dynamic CT perfusion image |
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| LIU Ke,TANG Wen-yuan. Experimental study on hemodynamics of traumatic brain injury using dynamic CT perfusion image[J]. Acta Academiae Medicinae Militaris Tertiae, 2008, 30(13): 1299-1302 |
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| Authors: | LIU Ke TANG Wen-yuan |
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| Affiliation: | LIU Ke1,2,TANG Wen-yuan1(1Department of Neurosurgery,The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,2Department of Neurosurgery,Chongqing Emergency Medical Center,Chongqing 400014,China) |
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| Abstract: | Objective To investigate the changes of region cerebral homodynamic and cerebral vascular autoregulation in traumatic brain injury(TBI) by dynamic CT perfusion(CTP) imaging in rat.Methods Forty-five SD rats underwent CTP,including 10 control rats and 35 TBI rats,on 1,6,24 h,and day 3,7,14,21 after TBI.The region of interest(ROI) was located near traumatic area within 2 mm and mirror area of relative brain hemisphere.False color pictures and dynamic rCBF,rCBV,MTT and PS were obtained in different time.Pathol... |
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| Keywords: | traumatic brain injury CT perfusion imaging homodynamic rat |
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