Prevalence of Autoantibodies to Cyclic Citrullinated Peptide in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: A French Multicenter Study |
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Authors: | Nicole Fabien Nils-Olivier Olsson Joëlle Goetz Catherine Johanet Andrée Escande Nathalie Bardin Marielle Sanmarco Chantal Andre Alain Chevailler René-Louis Humbel Pascale Chretien Jean-claude Monier Françoise Fortenfant Françoise Oksman Marie-France Taillefer Jean Sibilia |
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Institution: | (1) Department of Immunology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Inserm U851, 69495 Pierre-Benite Cedex, France;(2) Groupe d’Etude de l’Auto-Immunité (GEAI), 49933 Angers, France |
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Abstract: | Our objective was to evaluate the prevalence of autoantibodies to cyclic citrullinated peptides (anti-CCP aAbs) in a cohort
of patients with a variety of inflammatory or non-inflammatory rheumatic diseases other than rheumatoid arthritis (RA). Six
hundred and nine serum samples were tested for anti-CCP aAbs and for rheumatoid factor (RF) using enzyme-linked immunosorbent
assays and immunonephelometry. The prevalence of anti-CCP aAbs and RF reached 10% and 25%, respectively, using the positive
cutoff value suggested by the manufacturers. Using a higher cutoff value (50 U/ml) for both aAbs, the prevalence was lower
with 6% and 16%, respectively. The specificity of both markers for RA thus reached 94% and 84%, respectively. Anti-CCP aAbs
were found to be elevated in inflammatory and also in non-inflammatory rheumatic diseases in the same proportion. Clinical
data obtained for 36 positive patients showed that 17% developed RA within 5 years. In conclusion, anti-CCP aAbs are clearly
more specific than RF for RA. Follow-up of anti-CCP aAbs-positive patients with inflammatory or non-inflammatory rheumatic
diseases other than RA could be important considering the predictive value of these aAbs for the development of RA. |
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Keywords: | Autoantibodies to cyclic citrullinated peptides CCP Rheumatic diseases Rheumatoid arthritis |
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