| 东北雷公藤对胶原诱导实验性关节炎抑制作用的免疫学研究 Ⅲ。雷公藤给药对模型动物一般免疫功能状态的影响 |
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| 引用本文： | 张绍伦,崔新江. 东北雷公藤对胶原诱导实验性关节炎抑制作用的免疫学研究 Ⅲ。雷公藤给药对模型动物一般免疫功能状态的影响[J]. 吉林大学学报(医学版), 1990, 0(3) |
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| 作者姓名： | 张绍伦 崔新江 |
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| 作者单位： | 白求恩医科大学微生物学教研室(张绍伦)，白求恩医科大学微生物学教研室(崔新江) |
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| 摘 要： | 东北雷公藤给药对关节炎模型动物一般免疫功能状态的影响与在正常动物给药时所观察到的结果相似。给药能降低模型动物血清IgC的浓度;抑制ConA诱导的大鼠血单个核细胞体外增殖反应,抑制血单个核细胞产生IL-2的活性。但对LPS诱导的大鼠血单个核细胞体外增殖反应无明显抑制作用,这点与氢化考地松给药的效果不同。
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| 关 键 词： | 东北雷公藤 关节炎模型动物 IgG浓度 血单个核细胞增殖反应 IL—2产生 |
IMMUNOLOGICAL STUDY ON SUPPRESSIVE EFFECT OF TRIPTERYGIUM REGELLI ON COLLAGEN-INDUCEDEXPERIMENTAL ARTHRITISIII.INFLUENCE ON GENERAL IMMUNE FUNCTIONIN MODEL ANIMALS |
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| Zhang Shaolun,Cui Xinjiang. IMMUNOLOGICAL STUDY ON SUPPRESSIVE EFFECT OF TRIPTERYGIUM REGELLI ON COLLAGEN-INDUCEDEXPERIMENTAL ARTHRITISIII.INFLUENCE ON GENERAL IMMUNE FUNCTIONIN MODEL ANIMALS[J]. Journal of Jilin University: Med Ed, 1990, 0(3) |
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| Authors: | Zhang Shaolun Cui Xinjiang |
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| Affiliation: | Department of Microbiology |
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| Abstract: | The influence of Tripterygium regelli on the general immune function of the arthritis model animals was similar to that of the normal animals who received the drug. Administration of Tripterygium regelli lowered the concentration of IgG in serum of model animals and suppressed the proliferation of blood mononuclear cells induced by Con A in vitro and inhibited the IL-2 production of blood mononuclear cells. But there were noapparent inhibitory effect on the blood mononuclear cell proliferation of rats induced by LPS in vitro. |
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| Keywords: | Tripterygium regelli Arthritis model animalIgG level Proliferation reactionBlood mononuclear cells IL-2 production |
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