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Multiple Evanescent White Dot Syndrome: A Multimodal Imaging Study of Foveal Granularity |
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| Authors: | Alessandro Mantovani Giovanni Staurenghi Carl P Herbort Jr |
| Institution: | 1. Ophthalmology Unit, Ospedale Valduce, Como, Italy;2. Eye Clinic, Department of Biomedical and Clinical Science “L. Sacco”, Luigi Sacco Hospital, University of Milan, Milan, Italy;3. Retinal and inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi, Lausanne, Switzerland.;4. Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland |
| Abstract: | Purpose: To describe multiple evanescent white dot syndrome (MEWDS)-related foveal granularity features on different imaging modalities. Methods: Clinical and multi-imaging files from five patients affected by MEWDS were reviewed. Each image set included: blue fundus autofluorescence (BAF), near-infrared fundus autofluorescence (NIR-FAF), spectral-domain optical coherence tomography (SD-OCT), fluorescein (FA), and indocyanine green (ICGA) angiography. Foveal granularity features were analyzed and described for each technique at baseline and follow-up. Results: At baseline, 4/5 patients did not show white dots at funduscopic examination, but all subjects demonstrated hypo-fluorescent lesions on ICGA and areas of increased BAF. In all patients, foveal granularity was detectable on NIR-FAF as an irregular hypo-fluorescent area, persisting during follow-up visits. The corresponding SD-OCT scans revealed outer retinal layers’ disruption resolving overtime. Conclusions: Foveal granularity can be the sole presenting sign of MEWDS. NIR-FAF and SD-OCT should be considered as non-invasive investigations in the detection of MEWDS-related foveal granularity. |
| Keywords: | Autofluorescence fovea granularity MEWDS optical coherence tomography uveitis |