Urinary levels of 1-hydroxypyrene and health risk assessment in children living in Mexican communities with a high risk of contamination by polycyclic aromatic hydrocarbons (PAHs) |
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Authors: | Iván N. Pérez-Maldonado Ángeles C. Ochoa-Martínez Myrna L. López-Ramírez José A. Varela-Silva |
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Affiliation: | 1. Laboratorio de Toxicología Molecular, Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Coordinación para la Innovación y Aplicación de la Ciencia y la Tecnología (CIACYT), Universidad Autónoma de San Luis Potosí, San Luis Potosí, México;2. Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México;3. Unidad Académica Multidisciplinaria Zona Media, Universidad Autónoma de San Luis Potosí, Rioverde, San Luis Potosí, México;4. Facultad de Enfermería, Universidad Autónoma de Zacatecas, Zacatecas, México |
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Abstract: | Health complications have been associated with polycyclic aromatic hydrocarbons (PAHs) exposure, a widespread environmental pollutants family. Therefore, the objective of this investigation was to develop a probabilistic health risk evaluation (using Monte-Carlo simulation) in an infantile population living in areas with a high risk of pollution by PAHs (indoor wood combustion, brick kiln industry, municipal landfill, and low and high vehicular traffic) in Mexico. Urine samples were obtained from Mexican children (n = 135) and urinary 1-OHP concentrations (used as a PAHs biomarker) were quantified. Highest urinary 1-OHP concentrations were detected in children living in areas that use wood combustion as the principal indoor fuel (3.50 ± 0.95 µg/L). Nevertheless, estimated hazard quotients (HQ) lower than 1 were found in all assessed sites after Monte-Carlo analysis. Although HQ <1.0 (a toxic effect is not expected), more data are necessary to determine the real impact of PAHs exposure on children health status. |
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Keywords: | 1-hydroxypyrene health risk assessment México Monte Carlo simulation polycyclic aromatic hydrocarbons |
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