Comparison of the effect of two combinations of myo-inositol and D-chiro-inositol in women with polycystic ovary syndrome undergoing ICSI: a randomized controlled trial |
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| Authors: | Nicolas Mendoza Maria Paz Diaz-Ropero Miguel Aragon Vicente Maldonado Placido Llaneza Juan Lorente |
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| Institution: | 1. Obstetricia y Ginecologia, University of Granada, Granada, Spain;2. Clinica MARGEN, Calle Abu Said, n2 19, Granada, Spain;3. Biosearch Life, Granada, Spain;4. Complejo Hospitalario Torrecardenas, Almeria, Spain;5. Complejo Hospitalario de Jaen, Jaen, Spain;6. Hospital Universitario Central de Asturias, Oviedo, Spain;7. Department of Obstetrics and Gynecology, “Reina Sofía” University Hospital, Córdoba, Spain |
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| Abstract: | The purpose of this study was to evaluate the effect of two doses of D-chiro-inositol (DCI) in combination with Myo-inositol (MYO) in women with PCOS undergoing ICSI. This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12?weeks. The study group (SG) was administered 550?mg of MYO + 150?mg of DCI twice daily; the control group (CG) was administered 550?mg of MYO + 13.8?mg of DCI twice daily. The participants comprised 60 women with PCOS undergoing ICSI. At baseline, no differences were found between the two groups regarding age, BMI, HOMA-IR or testosterone levels. The pregnancy and live birth rates were significantly higher in the SG than in the CG (65.5 vs. 25.9 and 55.2 vs. 14.8, respectively) risk ratio (RR) = 0.4; 95%CI (0.2, 0.79); p?=?.003 and RR?=?0.27; 95%CI (0.10, 0.70); p?=?.002 respectively]. The risk of ovarian hyperstimulation syndrome (OHSS) was lower in the SG (3.44 vs. 18.5%, p?=?.07). The combination of MYO-DCI at high doses of DCI improves the pregnancy rates and reduces the risk of OHSS in women with PCOS undergoing ICSI. |
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| Keywords: | Myo-inositol D-chiro-inositol" target="_blank">D-chiro-inositol polycystic ovary syndrome ICSI pregnancy rate |
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