Improving psychological outcomes for orphans living with HIV in Tanzania through a novel intervention to improve resilience: findings from a pilot RCT

Parental death and HIV are associated with poor mental health for orphans in sub-Saharan Africa. This study aimed to evaluate a theory-based intervention for orphaned children on treatment in Tanzania, in terms of feasibility, acceptability and preliminary outcomes. A pilot RCT with nested focus group (FGD) allocated 48 children to usual care or residential “Memory Work Therapy”. Children completed outcome measures at T0 (baseline), T1 (2 weeks following intervention) and T2 (9 weeks from T0). Forty percent of eligible children assented. T1 intervention effects were found on all total measures: Brief Symptom Inventory d?=?0.99, p?d?=?0.65, p?=?.001; Strengths and Difficulties Questionnaire d?=?0.64, p?=?.002; Self-efficacy questionnaire for children both “social” and “emotional” subscales, d?=?0.54, p?=?.008 and d?=?0.63, p?=?.002, respectively. At T2, significant effects remained for all measures and SES effect increased from medium to large (T1?=?0.65, T2?=?1.33). FGD data found children valued a calm environment that met their basic needs, enabling them to reflect, highlight support resources, and strengthen ability to recognize personal skills. The intervention has strong feasibility and acceptability, with no attrition or missing data. Memory Work Therapy has high potential effect size and should be tested in a fully powered trial. Clinical trials.gov NCT02180750.