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Clinical Profile,Ultra-Wide-Field Fluorescence Angiography Findings,and Long-Term Prognosis of Uveitis in Tubulointerstitial Nephritis and Uveitis Syndrome at One Tertiary Medical Institute in China |
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| Authors: | Menglu Yang Ying Chi Chunying Guo Junwen Huang Li Yang Liu Yang |
| Institution: | 1. Department of Ophthalmology, Peking University First Hospital, Beijing, China;2. Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China;3. Peking University Institute of Nephrology, Beijing, China;4. Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China |
| Abstract: | Purpose: To analyze the clinical features and long-term prognosis of uveitis in tubulointerstitial nephritis and uveitis (TINU) syndrome in a cohort of Chinese patients. Methods: A total of 32 patients with TINU syndrome between 2000 - 2016 were analyzed retrospectively. Results: Mild anterior inflammation was observed in all cases. Ultra-wide-field fluorescence angiography (UWFA) was conducted on 13 patients, and peripheral vascular leakage was observed in 22/26 eyes (84.62%) compared with active anterior chamber inflammation in 13/26 eyes (50%). Three patients received increased corticosteroid dosage therapy on their first episode of uveitis guided by UWFA had stopped steroids without recurrence. Conclusion: The uveitis in TINU syndrome was mild. Corticosteroids were efficient in most cases, but a slower tapering and long-term treatment were required. UWFA is sensitive in detecting the activity of uveitis and might be useful in monitoring disease progression. Complete withdrawal of medication was difficult to achieve in some cases. |
| Keywords: | Ocular syndrome peripheral vascular leakage therapy tubulointerstitial nephritis and uveitis (TINU) syndrome ultra-wide-field fluorescence angiography |