索拉非尼滥用致肝损害

1例60岁男性患者肾癌术后自行口服索拉非尼0.2 g、2次/d。2个月后患者出现全身乏力伴巩膜黄染、尿黄。实验室检查：总胆红素（TBil）146μmol/L,直接胆红素（DBil）94μmol/L,丙氨酸转氨酶（ALT）959 U/L,天冬氨酸转氨酶（AST）1150 U/L,γ-L-谷氨酰转肽酶（γ-GT）507 U/L。停用索拉非尼,给予三磷酸胞苷二钠、还原型谷胱甘肽、腺苷蛋氨酸治疗。24 d后复查肝功能：TBil 19μmol/L,DBil 10μmol/L,ALT 54 U/L,AST 40 U/L,γ-GT 22 U/L。

Liver damage due to abuse of sorafenib

A 60-year-old male patient self-medicated with oral sorafenib 0.2 g twice daily after renal cancer surgery.After two months of treatment,he presented with generalized weakness,scleral jaundice and dark urine.Laboratory tests revealed the following levels: total bilirubin(TBil) 146 μmol/L,direct bilirubin(DBil) 94 μmol/L,alanine aminotransferase(ALT) 959 U/L,aspartate aminotransferase(AST) 1150 U/L and gamma-glutamyltransferase(γ-GT) 507 U/L.Sorafenib was stopped and he was given cytidine disodium triphosphate,reduced glutathione and ademetionine.Twenty-four days later,repeat liver function tests revealed the following levels: TBil 19 μmol/L,DBil 10 μmol/L,ALT 54 U/L,AST 40 U/L,γ-GT 22 U/L.