硫普罗宁致高热、肺水肿及胸腔积液

1例60岁女性患者因肝功能轻度异常口服硫普罗宁0.2 g,3次/d。约20 d后患者在服用硫普罗宁后十几分钟突然出现畏寒、发热,最高体温39.3℃。当地医院给予头孢呋辛、阿奇霉素、莫西沙星等药物治疗,但未停用硫普罗宁,患者症状无改善,且出现干咳、活动后气喘、肺水肿及胸腔积液,遂入我院。入院后仍给予抗感染治疗,但患者自行停用硫普罗宁,第2天患者体温即降至正常,4 d后患者各种症状好转出院。出院后2 d患者自行服用硫普罗宁0.2 g后十几分钟再次出现高热、畏寒,停药并给予退热处理,症状消失。

Hyperthermia,pulmonary edema,and pleural effusion due to tiopronines

A female patient aged 60 took tiopronine 0.2 g thrice daily by mouth for mild abnormal liver function.About 20 days later,the patient developed suddenly chill and fever with a peak temperature of 39.3℃ ten minutes after tiopronine administration.Cefuroxime,azithromycin,moxifloxacin,and other medications were given at a local hospital,but tiopronine was not withdrawn.Her symptoms did not improve and dry cough,short of breath with activity,pulmonary edema,and pleural effusion appeared.The patient then was admitted to our hospital.After admission,the patient still received anti-infective treatment,and she stopped tiopronine by herself.The next day,her temperature returned to within normal range and,four days later,all her symptoms relieved and she was discharged.Two days after discharge,hyperthermia and chill recurred ten minutes more after starting self-medication with tiopronine 0.2 g and her symptoms subsided after drug discontinuation and receiving antipyretic treatment.