生存素在骨肉瘤的表达及意义

目的　探讨生存素在骨肉瘤中的表达与骨肉瘤的生物学特性的关系。　方法　采用免疫组织化学SP法检测5 2例骨肉瘤、15例骨软骨瘤及15例正常骨质标本的生存素蛋白表达。　结果　生存素蛋白在骨肉瘤中的表达显著高于骨软骨瘤和正常骨质(P <0 .0 5 ) ,在肿瘤的侵袭转移方面差异有显著性(P <0 .0 5 ) ,而在性别、年龄、肿瘤直径、病理类型、病理分级及临床分期等方面差异无显著性(P >0 .0 5 )。　结论　生存素在侵袭转移的骨肉瘤呈高表达,提示其在骨肉瘤的发生和发展中起重要作用。

Expression and Significance of Survivin in Osteosarcoma

Objective To investigate the expression of survivin protein in osteosarcoma and clinical significance. Method Expression of survivin protein were detected by immunohistochemistry staining(SP) assay in 52 osteosarcoma cases, 15 osteochondroma cases and 15 normal bone. Results The survivin protein expression was higher in the osteosarcoma than in control groups(P<0.05). No significant differences were observed in sex, year, size of tumor, types of pathology, pathological grade and clinical stages. Conclusion The inhibitor of apoptosis protein survivin plays an important role in the tumor genesis and development of osteosarcoma and may be an important index in invasion and metastasis. Detecting the survivin protein may serve as a marker of predicting degree of maligmacy and prognosis of osteosarcoma, and will provide a new therapy target for the tumor.