| 尿毒症动脉粥样硬化的研究进展 |
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| 引用本文： | 唐学琴,甘 华,陈泽君. 尿毒症动脉粥样硬化的研究进展[J]. 医学综述, 2014, 0(1): 63-66 |
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| 作者姓名： | 唐学琴 甘 华 陈泽君 |
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| 作者单位： | [1]重庆医科大学附属第一医院肾脏内科,重庆400016 [2]成都市第三人民医院肾脏内科,成都610031 |
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| 摘 要： | 心血管疾病是引起终末期肾病患者死亡的主要因素,导致心血管疾病的关键因素则为动脉粥样硬化。慢性肾脏病患者动脉粥样硬化的发生率较同一年龄人群高510倍,发病年龄提前至3010倍,发病年龄提前至3040岁,被称为加速型动脉粥样硬化。该文主要从微炎症状态、高同型半胱氨酸血症、不同血液净化方式、营养不良、基因多态性与动脉粥样硬化关系等方面,介绍终末期肾病患者加速型动脉粥样硬化相关机制的研究进展,并简要介绍相关的干预措施。
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| 关 键 词： | 尿毒症 动脉粥样硬化 白细胞介素33 |
Progress in Study of Uremic Atherosclerosis |
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| Affiliation: | TANG Xue-qin , GAN Hua , CHEN Ze-jun ( 1. Department of Nephrology , Chongqing Medical University First Affiliated Hospital, Chongqing 400016, China ; 2. Department of Nephrology , Chengdu Third People＇s Hospital, Chengdu 610031, China) |
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| Abstract: | Cardiovascular disease is a major lethal factor of ESRD patients, and the key factor that leads to cardiovascular disease is atherosclerosis. The incidence of atherosclerosis in patients with kidney disease is 5-10 times more than that in healthy population of the same age, and the onset age of atherosclerosis is advan- cing to 30-40 years old, which is called the accelerated atherosclerosis. Here is to make a review of the research progress of accelerated atherosclerosis related mechanism in patients with ESRD from the perspec- tives of micminflammatory state,hyperhomocysteinemia, different modes of blood purification, malnutrition, and correlation between gene polymorphism and atherosclerotisis, and briefly introduce the relevant interventions. |
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| Keywords: | Uremia Atherosclerosis Interleukin-33 |
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