Genes mediating programmed cell death: an immunohistochemical study of bcl-2, c-myc and p53 expression in colorectal neoplasia |
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| Authors: | Nigel Scott Ian Martin Andrew S Jack Michael F Dixon and Philip Quirke |
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| Institution: | Department of Histopathology, Centre for Digestive Diseases;Department of Surgery, Centre for Digestive Diseases;Molecular Oncology, Centre for Cancer Research, University of Leeds;Haematological Malignancy Diagnostic Service, United Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX |
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| Abstract: | Aims—To describe the expression of three genes involved in the regulation of cell proliferation and programmed cell death (apoptosis) in normal, dysplastic and malignant large bowel epithelium, and to relate any alterations to important biological and clinical variables. |
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