男性激素避孕临床研究的某些进展

随着社会的发展 ,迫切需要研制可供男性选用、安全高效、可复性和可接受性均好的避孕药。男性激素类避孕是当今最有前途的方法之一 ,其基本原理是通过外源性激素来抑制垂体促性腺激素和睾丸内睾酮的合成与分泌 ,进而抑制精子发生 ;同时给予的外源雄激素维持男性性征和性功能。研究中的男性激素避孕方法 ,包括单用雄激素、雄激素与孕激素合用、GnRH类似物与雄激素合用、激素相关的免疫途径等 ,寻求更长效、使用更方便、副作用小的雄激素制剂也是当今研究的重点之一

Studies and Progress of Male Hormonal Contraception

It has become more and more urgent to develop a safe, effective, recoverable and acceptable contraceptive for males. Decades of studies have made much progress on male hormonal contraception, one of the promising contraceptive methods. The principle is based on the suppression of pituitary gonadotropin and intratesticular testosterone, then the suppression of spermatogenesis, and the supplement of androgen to maintain the male characteristics and sexual function. There are many male hormonal contraceptive methods being studied include androgen, androgen combined with progesterone, GnRH antagonists combined with androgen, as well as immunological methods. To develop a safe and convenient androgen preparation with longer action and fewer side effects is also one of the key items of present research in this field.