Serum insulin-like growth factor 1 in congenital heart disease |
| |
Authors: | JS Barton PC Hindmarsh MA Preece |
| |
Affiliation: | Growth Research Centre, Institute of Child Health, London. |
| |
Abstract: | Serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3), and a range of growth and nutritional variables were investigated in 62 infants with congenital heart disease and healthy controls. Infants with congenital heart disease were small, underweight, and had a reduced energy intake. Serum IGF-1 and IGFBP-3 concentrations were significantly reduced. Decreased IGF-1 and IGFBP-3 levels are observed in nutritional deficiency; similar findings in congenital heart disease suggest that undernutrition contributes to the poor growth of these infants. Serial measurements of serum IGF-1 and IGFBP-3 may be helpful in monitoring the effect of nutritional treatment in congenital heart disease. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|