生长抑素对Oddi括约肌功能的影响

为证实生长抑素对Ｏｄｄｉ括约肌功能的作用，用逆行胰胆管造影下Ｏｄｄｉ括约肌测压研究了生长抑素对２０例患者Ｏｄｄｉ括约肌运动功能的影响。２０例患者中胆总管结石６例，胆总管轻度扩张３例，肝门癌３例，未见明显异常者８例。用低顺应性水灌注系统，三通道测压导管，分别于用药前及静注生长抑素２５０μｇ１分钟后进行Ｏｄｄｉ括约肌测压，以观察Ｏｄｄｉ括约肌的基础压、收缩频率、收缩幅度、收缩间期、传播方式和胆管内压变化。结果显示：用药后Ｏｄｄｉ括约肌基础压降低、收缩频率减慢，其余指标无明显变化。我们认为：生长抑素对Ｏｄｄｉ括约肌有抑制性作用，有利于胆汁和胰液的排出。

EFFECT OF SOMATOSTATIN ON HUMAN SPHINCTER OF ODDI MOTILITY

The effect of somatostatin on the sphincter of Oddi was investigated in 20 subjects referred for endoscopic sphincter of Oddi manometry. Six patients had common bile duct dilatation, three had common bile duct slight dilatation, three had hepatic hilar carcinoma and eight had normal findings on endoscopic retrograde cholangiopancreatography. A triple-lumen low compliance system was used to record the sphincter of Oddi basal pressure, phasic contraction frequency, amplitude, duration, and direction of wave propagation before and after intravenous administration of somatostatin in a dose of 250 micrograms. After a mean latency period of 1 min, there were significant changes including decreased basal pressure (P < 0.01) and decreased frequency of wave contraction (P < 0.01). The amplitude and duration of wave contraction and wave propagation sequence were not significantly influenced. Thus somatostatin has a significant inhibitory effect on the sphincter of Oddi activity, which may be helpful for biliary and pancreatic flow.