| 丙泊酚的合成工艺改进 |
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| 引用本文： | 陈洪. 丙泊酚的合成工艺改进[J]. 齐鲁药事, 2013, 32(6): 328-329 |
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| 作者姓名： | 陈洪 |
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| 作者单位： | 陈洪 (上海现代哈森药业有限公司,河南,商丘,476000)； |
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| 摘 要： | 目的合成丙泊酚。方法在浓硫酸存在下,以对羟基苯甲酸(1)为起始原料,与异丙醇反应,生成4-羟基-3,5-二异丙基苯甲酸(2),2再与氢氧化钠条件下加热脱羧生成目标化合物丙泊酚。结果及结论合成丙泊酚总收率大于64%(以1计),纯度大于99%。
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| 关 键 词： | 丙泊酚 对羟基苯甲酸 合成 |
Synthesis of propofol |
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| CHEN Hong. Synthesis of propofol[J]. qilu pharmaceutical affairs, 2013, 32(6): 328-329 |
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| Authors: | CHEN Hong |
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| Affiliation: | CHEN Hong(Shanghai Modern Harsen Pharmaceutical Co.,Ltd.,Shangqiu 476000,China) |
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| Abstract: | Objective To synthesize propofol.Methods 4-hydroxy-3,5-diisopropylbenzoic acid(2) was produced with p-hydroxy benzoic acid(1) and isopropanol in the conditionof concentrated sulfuric acid.Propofol was synthesis by decarboxylation of 4-hydroxy-3,5-diisopropyl benzoic acid(2) in the condition of high boiling point solvent and metal hydroxide in inert atmosphere.Results and Conclusion The overall yield rate of propofol synthesized was 64% and its purity was more than 99%. |
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| Keywords: | Propofol p-hydroxy benzoic acid Synthesis |
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