近视性屈光参差患者双眼角膜生物力学及眼压特点的研究

目的观察近视性屈光参差患者双眼角膜生物力学及眼压的特点。设计回顾性病例系列。研究对象116例(232眼)近视性屈光参差患者。方法按每人双眼等效球镜度(SE)高低分为低SE眼和高SE眼,比较双眼标志角膜生物力学参数的角膜阻力因子量(CRF)、角膜滞后量(CH)和眼压的特点;根据双眼间等效球镜度差值分为组1(SE差值2.5～3.0 D,37例)、组2(SE差值﹥3.0 D～6.0 D,44例)和组3(SE差值>6.0 D,35例),比较不同屈光参差程度组内低SE眼和高SE眼CRF、CH和眼压的特点。主要指标CRF、CH、角膜补偿眼压。结果总体低SE眼和高SE眼间的CRF分别为(10.40±1.74)mm Hg和(10.38±1.63)mmHg,差异无统计学意义(t=0.113,P=0.683),CH分别为(9.71±1.68)mm Hg和(9.66±1.90)mm Hg,差异亦无统计学意义(t=0.144,P=0.886)。在屈光参差程度不同的三组中,双眼间低SE眼与高SE眼CRF的差异均无统计学意义,组1:(10.58±1.74)mm Hg,(10.65±1.61)mm Hg(t=-0.175,P=0.862);组2:(10.31±1.88)mm Hg,(10.14±1.58)mm Hg(t=0.434,P=0.666);组3:(10.35±1.47)mm Hg,(10.31±1.65)mm Hg(t=-0.141,P=0.903)。各组双眼间CH差异亦均无统计学意义,组1:(9.66±1.59)mm Hg,(9.74±1.52)mm Hg(t=-0.210,P=0.834);组2:(9.89±1.90)mm Hg,(9.83±2.21)mm Hg(t=0.122,P=0.903);组3:(9.59±1.35)mm Hg,(9.35±1.71)mm Hg(t=0.336,P=0.512)。总体低SE眼和高SE眼间的角膜补偿眼压分别为(18.37±3.58)mm Hg和(18.67±3.48)mm Hg,也未发现差异有统计学意义(t=-0.607,P=0.545)。结论近视性屈光参差患者双眼间角膜生物力学参数及眼压无显著性差异。

Corneal biomechanical properties and intraocular pressure in myopic anisometropia

Objective To investigate corneal biomechanical properties and intraocular pressure in myopic anisometropia. Design Retrospective case series. Participants 116 patients （232 eyes） with myopic anisometropia. Methods According to spherical equivalent （SE） of anisometropic eyes, they were divided into low SE eye and high SE eye. Then according to the degree of myopic anisometropia, all patients were divided into three groups： group 1 （the difference of SE was 2.5-3.0 D）, group 2 （〉3.0-6.0 D） and group 3 （〉6.0 D）. Their corneal biomechanical properties and intraocular pressure between anisometropic eyes were compared, including corneal resistance factor（CRF）, corneal hysteresis（CH） and intraocular pressure. Main Outcome Measures CRF, CH, corneal compensated intraocular pressure. Results In low SE eyes and high SE eyes for all patients, mean CRF was 10.40±1.74 mm Hg and 10.38±1.63 mm Hg （t= 0.113, P=0.683）, mean CH was 9.71±1.68 mm Hg and 9.66±1.90 mm Hg （t=0.144,P=0.886）. In group 1, mean CRF was 10.58±1.74 mm Hg and 10.65±1.61 mm Hg （t=-0.175, P=-0.862）, mean CH was 9.66±1.59 mm Hg and 9.74±1.52 mm Hg （t=-0.210, P=0.834）. In group 2, mean CRF was 10.31±1.88 mm Hg and 10.14±1.58 mm Hg （t=0.434,P=0.666）, mean CH was 9.89±1.90 and 9.83±2.21 （t= 0.122, P=0.903）. In group 3, mean CRF was 10.35±1.47 mm Hg and 10.31±1.65 mm Hg （t=-0.141, P=0.903）, mean CH was 9.59±1.35 mm Hg and 9.35±1.71 mm Hg （t=0.336, P=0.512）. In low SE eyes and high SE eyes for all patients,corneal compensated intraocular pressure （IOPcc） was 18.37±3.58 mm Hg and 18.67±3.48 mmHg. The difference was not significant （t=-0.607, P=0.545）. Conclusion There is no significant difference in corneal biomechanical properties and intraocular pressure between anisometropic eyes.