| 海参虫草复配物辅助降血糖作用研究 |
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| 引用本文： | 傅佳,王静凤,李晓林,李冰,王玉明,薛长湖. 海参虫草复配物辅助降血糖作用研究[J]. 营养学报, 2011, 33(1) |
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| 作者姓名： | 傅佳 王静凤 李晓林 李冰 王玉明 薛长湖 |
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| 作者单位： | 中国海洋大学食品科学与工程学院,青岛,266003 |
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| 基金项目： | 国家高技术研究发展计划(863)项目，国家科技支撑计划，国家自然科学基金 |
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| 摘 要： | 目的探讨海参虫草复配物对糖尿病大鼠糖代谢的调节作用。方法采用腹腔注射链脲佐菌素的方法建立糖尿病大鼠模型。利用海参虫草复配物(分别为300、1200mg/kg.bw)灌胃模型大鼠35d,观察其对大鼠空腹血糖、葡萄糖耐量、血清胰岛素、糖化血红蛋白、糖化血清蛋白以及肌、肝糖元等的影响。结果海参虫草复配物能显著降低糖尿病大鼠空腹血糖含量(P<0.05),提高葡萄糖耐量水平(P<0.05,P<0.01);显著降低糖化血红蛋白和糖化血清蛋白含量(P<0.05,P<0.01);显著提高糖尿病大鼠血清中胰岛素含量(P<0.05)、胰岛素分泌指数(P<0.05)和β细胞功能指数(P<0.05);增加肌、肝糖元含量(P<0.01)。结论海参虫草复配物能改善糖尿病大鼠的糖代谢水平,具有较好的辅助降糖效果。
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| 关 键 词： | 海参虫草复配物 胰岛素 糖化血红蛋白 糖化血清蛋白 |
THE ANTIHYPERGLYCEMIC EFFECT OF MIXTURE OF APOSTICHOPUS JAPONICUS AND CORDYCEPS MILITARIS IN DIABETIC RATS |
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| FU Jia,WANG Jing-feng,LI Xiao-lin,LI Bing,WANG Yu-ming,XUE Chang-hu. THE ANTIHYPERGLYCEMIC EFFECT OF MIXTURE OF APOSTICHOPUS JAPONICUS AND CORDYCEPS MILITARIS IN DIABETIC RATS[J]. Acta Nutrimenta Sinica, 2011, 33(1) |
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| Authors: | FU Jia WANG Jing-feng LI Xiao-lin LI Bing WANG Yu-ming XUE Chang-hu |
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| Affiliation: | FU Jia,WANG Jing-feng,LI Xiao-lin,LI Bing,WANG Yu-ming,XUE Chang-hu(College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China) |
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| Abstract: | Objective To investigate the effect of the mixture of Apostichopus japonicus and Cordyceps militaris on the glucose metabolism in diabetic rats induced by STZ.Method The diabetic rat model was established by intraperitoneal injection of STZ.The model rats were administered the mixture of A.japonicus and C.militaris by oral for 35 d,and the effect on fasting plasma glucose,glucose tolerance,serum insulin,glycosylated hemoglobin,glycosylated serum protein and muscle glycogen,as well as the liver glycogen was ... |
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| Keywords: | mixture of Apostichopus japonicas and Cordyceps militaris insulin glycosylated hemoglobin glycosylated serum protein |
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