| 宫颈癌中白细胞介素-10、白细胞介素-12检测及其意义 |
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| 引用本文： | 农文政,杜萍,甘精华,黄丽珍. 宫颈癌中白细胞介素-10、白细胞介素-12检测及其意义[J]. 右江医学, 2011, 39(1): 14-16. DOI: 10.3969/j.issn.1003-1383.2011.01.005 |
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| 作者姓名： | 农文政 杜萍 甘精华 黄丽珍 |
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| 作者单位： | 广西壮族自治区民族医院,广西南宁,530001 |
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| 摘 要： | 目的检测宫颈癌患者白细胞介素-10(IL-10)及白细胞介素-12(IL-12)浓度。方法用酶联免疫法(ELISA)检测30例宫颈癌患者,25例健康成年人血清IL-10及IL-12浓度。结果宫颈癌组IL-10浓度明显高于对照组,宫颈癌组IL-12浓度明显低于对照组。IL-10浓度在≤50岁年龄组明显高于>50岁年龄组,低分化癌组明显高于高、中分化癌组,有淋巴结转移组明显高于无淋巴结转移组、晚期临床分期组(Ⅲ/Ⅳ)明显高于早期临床分期组(Ⅰ/Ⅱ),P均<0.01但在不同病理类型浓度差异无统计学意义(P>0.05),IL-12浓度在低分化癌组明显低于高、中分化癌组,有淋巴结转移组明显低于无淋巴结转移组、晚期临床分期组(Ⅲ/Ⅳ)明显低于早期临床分期组(Ⅰ/Ⅱ),P均<0.01,但在不同年龄组及病理类型浓度差异无统计学意义(P>0.05),而且IL-10及IL-12浓度呈负相关关系。结论宫颈癌中高浓度的IL-10可能产生对IL-12的拮抗作用,损害机体肿瘤免疫,促进肿瘤发展,检测IL-10和IL-12可反映宫颈癌病期、判断疗效和估计预后。
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| 关 键 词： | 宫颈癌 白细胞介素-10 白细胞介素-12 |
The examination and clinical significance of IL-10 and IL-12 in cervical cancer |
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| NONG Wenzheng,Du Ping,GAN Jinghua,HUANG Lizhen. The examination and clinical significance of IL-10 and IL-12 in cervical cancer[J]. Youjiang Medical Journal, 2011, 39(1): 14-16. DOI: 10.3969/j.issn.1003-1383.2011.01.005 |
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| Authors: | NONG Wenzheng Du Ping GAN Jinghua HUANG Lizhen |
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| Affiliation: | NONG Wenzheng,Du Ping,GAN Jinghua,HUANG Lizhen(Guangxi minzu Hospital,Nanning Guangxi,530001 China) |
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| Abstract: | Objective To investigate the clinical significance of interleukin-10(IL-10)and interleukin-12(IL-12) in cervical cancer.Methods 63 cervical cancer patients and 22 healthy people were examined the level of IL-10 and IL-12 in the serum by ELISA assay.Results The level of IL-10 in cervical cancer patients was higher significantly than that in healthy people,while the level of IL-12 was lower.The level of IL-10 in those younger than 50 years old,poorly differentiated carcinoma patients,patients with lymphatic m... |
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| Keywords: | Cervical cancer Interleukin-10 Interleukin-12 |
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