Roundabout4在肿瘤血管新生及细胞迁移中作用的研究进展

视网膜新生血管性疾病是世界范围内最严重的致盲性眼病之一，包括糖尿病视网膜病变、年龄相关性黄斑变性等。近年来普遍认为血管生长因子是调控视网膜内皮细胞增生和新生血管形成的最主要因素。Roundabout 4（Rob04）是近年发现的一种跨膜蛋白，特异性表达于血管生成活跃的内皮细胞表面。目前的研究认为，Rob04能够调控内皮细胞的迁移及血管新生，参与血管生长因子的信号转导途径，在血管稳定性的调节中发挥重要作用。对Rob04的深入研究将有助于揭示视网膜新生血管性疾病的形成机制。就Rob04的分布、结构、配体及在血管发生、内皮细胞迁移中的作用及与眼部相关的基础研究进行综述。

Research progress of Roundabout 4 in tumor angiogenesis and endothelial cell migration

Retinal neovascularization ( RNV) is a serious and causing-blindness eye disease in human beings. It occurs in severe eye diseases including diabetic retinopathy age-related tnacular degeneration etc.. In recent years vascular growth factor is the most important factors in controlling retinal endothelium proliferation and retinal neovacularization. Roundabout 4 ( Robo4 also known as Magic Roundabout) is a transmembrane receptor protein. Expression of Robo4 is restricted exclusively to sites of active angiogenesis. It has been recognized that Robo4 can control endothelial cell migration and the sprouting of new blood vessels neutralize signaling through the vascular growth factor and maintain vessel integrity. These findings could lead to new therapeutic target for RNV. The roles of Robo4 in angiogenesis and endothelial cell migration were discussed and basic research in the eye was reviewed.