早产儿脑室周围白质软化的防治进展

早产儿脑室周围白质软化(PVL)已成为导致早产儿神经发育、行为障碍及脑瘫最重要因素,严重影响早产儿的生存质量。探索PVL的防治方法具有重要意义,其中预防早产,防治宫内感染及围生期窒息,防治出生后早产儿常见的并发症,维持脑血流动力学稳定对减少PVL的发生有重要临床意义;谷氨酸受体拮抗剂、神经营养因子、促红细胞生成素、白细胞介素10及甲状腺激素等则可能有效减轻PVL脑损伤,改善预后、降低伤残率。本文就近年来有关早产儿PVL的防治方法予以综述。

Progress in Prevention and Treatment of Periventricular Leukomalacia in Premature Infant

Periventricular leukomalacia（PVL） is the main cause of cerebral palsy,defection of neurode- velopment and behavior handicap in premature infants,which effects premature infants seriously. It is critical for exploring for preventative and therapeutic strategies for PVL. There are some important strategies to decrease PVL, including preventing premature delivery, preventing and treating intrauterine infection, pefinatal asphyxia, common complication of preterm, and maintaining stability of cerebral hemodynamics. Glutamate receptor antagonists, neurotrophic factors, erythropoietin, IL-10 and thyroxine can alleviate effectively the brain injury, of PVL, and improve the prognosis and reducing disability rates. This paper reviews the prevention and cure approach to PVL in premature infant in recent years.